{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:41:36Z","timestamp":1747186896201,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Budd\u2010Chiari syndrome (BCS) is a rare and potentially life\u2010threatening disorder characterized by obstruction of the hepatic outflow tract. It is unknown whether patients with BCS represent a high risk for severe disease and mortality from coronavirus disease 2019 (COVID\u201019). Thus, we aimed to assess hospitalization rates, severe disease, all\u2010cause mortality, intensive care unit (ICU) requirement and acute kidney injury (AKI) from COVID\u201019 diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods &amp; Results<\/jats:title><jats:p>We identified 467 patients with BCS with COVID\u201019, 96\u2009427 non\u2010chronic liver disease (CLD) and 9652 non\u2010BCS CLD. The BCS and non\u2010CLD cohorts (<jats:italic>n<\/jats:italic>\u00a0=\u00a0467 each) and BCS and non\u2010BCS CLD (<jats:italic>n<\/jats:italic>\u00a0=\u00a0440 each) were well balanced after propensity matching. When compared to the non\u2010CLD cohort, the BCS group had a higher risk of all\u2010cause mortality (5.1% vs. 2.4%, HR 2.18; 95% CI, 1.08\u20134.40), severe disease (6.0% vs. 2.4%, HR 2.20; 95% CI, 1.09\u20134.43), hospitalization (24.6% vs. 13.1%, HR 1.77; 95% CI, 1.30\u20132.42) and AKI (7.9% vs. 2.8%, HR 2.57; 95% CI, 1.37\u20134.85), but no significant differences in ICU requirements (2.4% vs. 2.1%, HR 0.75; 95% CI, 0.27\u20132.08) at 60\u2010days time points. When compared to the non\u2010BCS CLD cohort, the BCS group had a higher risk of all\u2010cause mortality (3.6% vs. 2.5%, HR 3.94; 95% CI, 1.31\u201311.79), hospitalization (29.8% vs. 21.6%, HR 1.43; 95% CI, 1.09\u20131.86), but differences in ICU requirements (HR 0.90 (0.38\u20132.12)), AKI (HR 1.41 (0.86\u20132.30)) or severe disease (HR 1.92 (0.99\u20133.71)) did not reach statistical significance at 60\u2010day follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, COVID\u201019 infection in patients with BCS is associated with poor outcomes. Patients with BCS infected with COVID\u201019 carry a significantly higher risk of hospitalization and all\u2010cause mortality and a possible effect on severe disease and AKI compared with COVID\u201019 patients without CLD or with non\u2010BCS\u2010CLD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15553","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T08:05:20Z","timestamp":1677225920000},"page":"1141-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk of severe disease and mortality of <scp>COVID<\/scp>\u201019 in patients with <scp>Budd\u2010Chiari<\/scp> syndrome: A population\u2010based matched cohort study"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9452-7377","authenticated-orcid":false,"given":"Arunkumar","family":"Krishnan","sequence":"first","affiliation":[{"name":"Section of Gastroenterology and Hepatology West Virginia University School of Medicine  Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin V.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Gastroenterology, Metabolic diseases and Intensive Care University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4224-4703","authenticated-orcid":false,"given":"J\u00f6rn M.","family":"Schattenberg","sequence":"additional","affiliation":[{"name":"Metabolic Liver Research Program, Department of Medicine I University Medical Center Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-3526","authenticated-orcid":false,"given":"Saleh A.","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Liver Transplant Center King Faisal Specialist Hospital &amp; Research Center  Riyadh Saudi Arabia"},{"name":"Division of Gastroenterology and Hepatology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i1.8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006520"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-020-02616-5"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8407990"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.12.032"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.02.015"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100639"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2020.08.005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.213371"},{"issue":"22","key":"e_1_2_5_11_1","article-title":"Three\u2010fold increased risk of death in Budd\u2010Chiari syndrome compared to matched controls: A population\u2010based cohort study","volume":"1542","author":"\u00c5berg F","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.705908"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.734005"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31726"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31646"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-32-9232-1_6"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.15553","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T02:18:52Z","timestamp":1702433932000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.15553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,8]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/liv.15553"],"URL":"https:\/\/doi.org\/10.1111\/liv.15553","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"type":"print","value":"1478-3223"},{"type":"electronic","value":"1478-3231"}],"subject":[],"published":{"date-parts":[[2023,3,8]]},"assertion":[{"value":"2022-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}