{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:00:03Z","timestamp":1792036803706,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Spleen stiffness measurement (SSM) by vibration\u2010controlled transient elastography (VCTE) has been tested in a limited number of studies versus hepatic venous pressure gradient (HVPG), especially with the 100\u2009Hz spleen\u2010specific module. The current study aims to evaluate the diagnostic performance of this novel module for detecting clinically significant portal hypertension (CSPH) in a cohort of compensated patients with metabolic\u2010associated fatty liver disease (MAFLD) as the main aetiology and to improve the performance of the Baveno VII criteria for CSPH diagnosis by including SSM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective single\u2010centre study including patients with available measurements of HVPG, Liver stiffness measurement (LSM) and SSM by VCTE with the 100\u2009Hz module. Area under the receiver operating characteristic (AUROC) curve analysis was conducted to identify dual cut\u2010offs (rule\u2010out and rule\u2010in) associated with the absence\/presence of CSPH. The diagnostic algorithms were adequate if negative predictive value (NPV) and positive predictive values (PPV) were &gt;90%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 85 patients were included, 60 MAFLD and 25 non\u2010MAFLD. SSM showed a good correlation with HVPG (MAFLD:\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.74;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001; non\u2010MAFLD:\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.62;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0011). In MAFLD patients, SSM had a high accuracy in discarding\/diagnosing CSPH (cut\u2010off values of &lt;40.9 and &gt;49.9\u00a0kPa, AUC 0.95). The addition of these cut\u2010offs in a sequential or combined approach to the Baveno VII criteria significantly reduced the grey zone (60% vs. 15%\u201320%), while maintaining adequate NPV and PPV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings support the utility of SSM for diagnosing CSPH in MAFLD patients and demonstrate that the addition of SSM to the Baveno VII criteria increases accuracy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15561","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T10:54:38Z","timestamp":1678704878000},"page":"1446-1457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["High accuracy of spleen stiffness measurement in diagnosing clinically significant portal hypertension in metabolic\u2010associated fatty liver disease"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7894-2338","authenticated-orcid":false,"given":"Aitor","family":"Odriozola","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL) Marqu\u00e9s de Valdecilla University Hospital  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Puente","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL) Marqu\u00e9s de Valdecilla University Hospital  Santander 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8864-3833","authenticated-orcid":false,"given":"Mar\u00eda T.","family":"Arias\u2010Loste","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL) Marqu\u00e9s de Valdecilla University Hospital  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Redondo","sequence":"additional","affiliation":[{"name":"Statistical and Bioinformatic Unit Valdecilla Research Institute (IDIVAL)  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Rivas","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL) Marqu\u00e9s de Valdecilla University Hospital  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"F\u00e1brega","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL) Marqu\u00e9s de Valdecilla University Hospital  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8248-0172","authenticated-orcid":false,"given":"Javier","family":"Crespo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL) Marqu\u00e9s de Valdecilla University Hospital  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5255-9445","authenticated-orcid":false,"given":"Jos\u00e9 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