{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:45:54Z","timestamp":1787503554666,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T00:00:00Z","timestamp":1682208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204122"],"award-info":[{"award-number":["82204122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903382"],"award-info":[{"award-number":["81903382"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20220320"],"award-info":[{"award-number":["BK20220320"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20190652"],"award-info":[{"award-number":["BK20190652"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M701757"],"award-info":[{"award-number":["2021M701757"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2019RU038"],"award-info":[{"award-number":["2019RU038"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Physical activity, sedentary behaviour, and genetic variants have been associated with the nonalcoholic fatty liver disease (NAFLD). However, whether and how the degree of healthy activity patterns may modify the impact of genetic susceptibility on NAFLD remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Behaviour activity factors were determined according to total physical activity (TPA) and sedentary time. The polygenic risk score (PRS) was calculated by variants in\n                      <jats:italic>PNPLA3<\/jats:italic>\n                      ,\n                      <jats:italic>TM6SF2<\/jats:italic>\n                      ,\n                      <jats:italic>MBOAT7<\/jats:italic>\n                      , and\n                      <jats:italic>GCKR<\/jats:italic>\n                      . Cox regression was used to analyse the associations of genetic and behaviour activity factors with incident NAFLD in the UK Biobank (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009338\u2009087).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a median follow\u2010up of 12.4\u2009years, 3201 incident NAFLD cases were ascertained. Analyses of TPA and sedentary time simultaneously showed a dose\u2013response association with the risk of NAFLD (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      \u2009&lt;\u2009.001). The association of behaviour activity patterns with NAFLD varied by genetic variants. Of the subjects with high genetic risk, we observed a null protective effect of moderate or high TPA on NAFLD risk, while sitting less than three hours a day significantly decreased the risk of NAFLD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20093.50\u2009\u00d7\u200910\n                      <jats:sup>\u22124<\/jats:sup>\n                      ). The high genetic risk of NAFLD can also be offset by the combination of moderate physical activity and shorter sedentary time. Moreover, the high genetic risk group has the greatest reduction of 10\u2010year absolute risk (6.95 per 1000 person\u2010years) if reaching both healthy activities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Moderate\u2010to\u2010high physical activity and favourable sedentary behaviour may be lifestyle modifications in preventing NAFLD, which could offset the harmful effect of predisposing genetic factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15588","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T01:31:00Z","timestamp":1682299860000},"page":"1287-1297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Behavioural activity pattern, genetic factors, and the risk of nonalcoholic fatty liver disease: A prospective study in the\n                    <scp>UK<\/scp>\n                    Biobank"],"prefix":"10.1111","volume":"43","author":[{"given":"Xinyuan","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Epidemiology, China International Cooperation Center on Environment and Human Health, Center for Global Health, School of Public Health Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, China International Cooperation Center on Environment and Human Health, Center for Global Health, School of Public Health Nanjing Medical University  Nanjing China"},{"name":"Department of Infectious Disease The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, China International Cooperation Center on Environment and Human Health, Center for Global Health, School of Public Health Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, China International Cooperation Center on Environment and Human Health, Center for Global Health, School of Public Health Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, China International Cooperation Center on Environment and Human Health, Center for Global Health, School of Public Health Nanjing Medical University  Nanjing China"},{"name":"The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University  Suzhou 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