{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:45:36Z","timestamp":1790379936634,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T00:00:00Z","timestamp":1682208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Fatty change is commonly observed in hepatocellular carcinoma (HCC); however, the characteristics of steatotic and steatohepatitic HCCs are not well understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included patients with HCCs who underwent resection between January 2014 and December 2019 to evaluate clinicopathological and magnetic resonance imaging features. Tumours were categorized as magnetic resonance imaging\u2010steatotic, pathology\u2010steatotic and steatohepatitic HCCs and were defined as HCCs with \u226550% steatosis on in\u2010and\u2010oppose phase images, \u226534% tumour cells with lipid droplets and \u226550% tumour areas with steatohepatitic features on light microscopy respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 465 HCCs, 38 (8%), 23 (5%) and 15 (3%) were diagnosed as magnetic resonance imaging\u2010steatotic, pathology\u2010steatotic and steatohepatitic HCCs respectively. These HCC variants were less likely to be associated with hepatitis B virus infections than with type 2 diabetes mellitus, metabolic syndrome, non\u2010tumour liver steatosis and steatohepatitis. Moreover, microvascular invasion was less likely to be associated with them than either tumour size or differentiation. Type 2 diabetes and non\u2010tumour steatosis were independent risk factors for magnetic resonance imaging\u2010steatotic HCCs. Pathology\u2010steatotic HCCs and steatohepatitic HCCs were significantly associated with magnetic resonance imaging\u2010steatotic HCCs. A targetoid appearance in the transitional or hepatobiliary phase was also more prevalent in steatohepatitic\u2010HCCs than in non\u2013steatohepatitic\u2010HCCs. When magnetic resonance imaging\u2010steatotic HCCs were combined with one or more ancillary features, the sensitivity and specificity were 60% and 97% respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Underlying fatty liver disease and metabolic syndrome are strongly associated with both steatotic and steatohepatitic HCCs. Clinicoradiological characteristics help identify steatohepatitic HCC with high specificity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15589","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T05:31:05Z","timestamp":1682314265000},"page":"1332-1344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Steatotic hepatocellular carcinoma: Association of <scp>MRI<\/scp> findings to underlying liver disease and clinicopathological characteristics"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7626-194X","authenticated-orcid":false,"given":"Jae Hyon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Radiology, Research Institute of Radiological Science, Center for Clinical Imaging Data Science, Severance Hospital Yonsei University College of Medicine  Seoul South 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