{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:57:50Z","timestamp":1779890270579,"version":"3.53.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019TQ0008"],"award-info":[{"award-number":["2019TQ0008"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M670071"],"award-info":[{"award-number":["2020M670071"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["BMU2022PY014"],"award-info":[{"award-number":["BMU2022PY014"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2020YFC2004703"],"award-info":[{"award-number":["2020YFC2004703"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) and the newly proposed metabolic\u2010associated fatty liver disease (MAFLD) were each associated with subclinical atherosclerosis. However, there is limited evidence on risk of atherosclerosis in individuals who meet the criteria for one but not the other. We aimed to investigate the associations of MAFLD or NAFLD status with site\u2010specific and multiple\u2010site atherosclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective cohort study involving 4524 adults within the MJ health check\u2010up cohort. Logistic regression model was used to estimate odds ratios (ORs) and confidence intervals (CIs) for subclinical atherosclerosis (elevated carotid intima\u2010media thickness [CIMT], carotid plaque [CP], coronary artery calcification [CAC] and retinal atherosclerosis [RA]) associated with MAFLD or NAFLD status, MAFLD subtypes and fibrosis status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MAFLD was associated with higher risks of elevated CIMT, CP, CAC and RA (OR: 1.41 [95% CI 1.18\u20131.68], 1.23 [1.02\u20131.48], 1.60 [1.24\u20132.08], and 1.79 [1.28\u20132.52], respectively), whereas NAFLD per se did not increase risk of atherosclerosis except for elevated CIMT. Individuals who met both definitions or the definition for MAFLD but not NAFLD had higher risk of subclinical atherosclerosis. Among MAFLD subtypes, MAFLD with diabetes had the highest risk of subclinical atherosclerosis, but the associations did not differ by fibrosis status. Stronger positive associations were observed of MAFLD with multiple\u2010site than single\u2010site atherosclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Chinese adults, MAFLD was associated with subclinical atherosclerosis, with stronger associations for multiple\u2010site atherosclerosis. More attention should be paid to MAFLD with diabetes, and MAFLD might be a better predictor for atherosclerotic disease than NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15591","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T07:55:33Z","timestamp":1687247733000},"page":"1691-1698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Metabolic\u2010associated fatty liver disease in relation to site\u2010specific and multiple\u2010site subclinical atherosclerosis"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1794-510X","authenticated-orcid":false,"given":"Xinyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health Peking University  Beijing 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Public Health and Epidemic Preparedness and Response  Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases Ministry of Education, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canqing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health Peking University  Beijing China"},{"name":"Peking University Center for Public Health and Epidemic Preparedness and Response  Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases Ministry of Education, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchun","family":"Yin","sequence":"additional","affiliation":[{"name":"MJ Health Care Group  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing MJ Health Check\u2010up Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Deng","sequence":"additional","affiliation":[{"name":"Meinian Institute of Health  Beijing China"},{"name":"Department of Social Medicine and Health Education, School of Public Health Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Meinian Institute of Health  Beijing China"},{"name":"Peking University Health Science Center Meinian Public Health Institute  Beijing China"},{"name":"Peking University Center for Public Health and Epidemic Preparedness and Response  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health Peking University  Beijing China"},{"name":"Peking University Center for Public Health and Epidemic Preparedness and Response  Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases Ministry of Education, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4826-8861","authenticated-orcid":false,"given":"Yuanjie","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health Peking University  Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases Ministry of Education, Peking University  Beijing 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