{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T14:07:38Z","timestamp":1769177258775,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T00:00:00Z","timestamp":1682812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Glecaprevir and Pibrentasvir (G\/P) determine high rates of sustained virological response (SVR) with optimal safety profile in patients with chronic hepatitis C virus (HCV) infection. The efficacy and safety of G\/P in Caucasian patients aged 75\u2009years and older have not been widely analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective multicentre real\u2010world study enrolling all consecutive patients 75\u2009years and older who received G\/P between October 2017 and January 2022 at five referral centres in Italy. SVR was analysed by intention\u2010to\u2010treat (ITT) and per\u2010protocol analyses (PP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 570 patients met the inclusion criteria and were analysed: mean age was 80 (75\u201397) years, 356 (62%) were females, 52% (298\/570) had HCV\u20101, 44% (252\/570) had HCV\u20102 and 137 (24%) patients had liver cirrhosis. Four hundred and sixty\u2010three (81%) patients were taking at least one concomitant drug, with 144 (25%) taking \u22655 concomitant drugs. G\/P was given for 8\u2009weeks in 488 patients (86%). During treatment, 48 patients (8%) reported side effects, with 10 (2%) patients discontinuing treatment prematurely. Two patients developed treatment\u2010unrelated serious adverse events. Overall, the SVR rate was 97.9% (558\/570) by ITT analysis and 99.6% (558\/560) by PP analysis. SVR rates remained consistently high among subgroup analysis stratified by genotype, treatment duration, fibrosis stage and concomitant medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with G\/P achieved 97.9% SVR rates in HCV patients older than 75\u2009years of age. Safety was optimal with only 2% of patients discontinuing early.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15599","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T06:30:26Z","timestamp":1682922626000},"page":"1440-1445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Glecaprevir\/Pibrentasvir is safe and effective in Italian patients with chronic hepatitis C aged 75\u2009years or older: A multicentre study"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6466-1412","authenticated-orcid":false,"given":"Nicola","family":"Pugliese","sequence":"first","affiliation":[{"name":"Division of Internal Medicine and Hepatology, Department of Gastroenterology IRCCS Humanitas Research Hospital  Rozzano Italy"},{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0287-1059","authenticated-orcid":false,"given":"Vincenza","family":"Calvaruso","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology, PROMISE University of Palermo  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0550-8201","authenticated-orcid":false,"given":"Mario","family":"Masarone","sequence":"additional","affiliation":[{"name":"Internal Medicine and Hepatology Unit, Department of Medicine, Surgery and Dentistry, \u201cScuola Medica Salernitana\u201d University of Salerno  Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0019-1153","authenticated-orcid":false,"given":"Roberta","family":"D'Ambrosio","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Battistella","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology University of Padua  Padua Italy"},{"name":"Gastroenterology and Multivisceral Transplant Unit Azienda Ospedale\u2010Universit\u00e0 di Padova  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0383-6121","authenticated-orcid":false,"given":"Anna","family":"Licata","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties (PROMISE) University of Palermo  Palermo 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