{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:30:29Z","timestamp":1785601829880,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,8]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>Infection with the hepatitis D virus (HDV) causes the most severe form of viral hepatitis with a high risk to develop clinical complications of liver disease. In addition, hepatitis delta has been shown to be associated with worse patient\u2010reported outcomes. Until recently, only pegylated interferon alfa could be used to treat hepatitis delta.<\/jats:p><\/jats:sec>Methods<\/jats:title>Here, we investigated quality of life (QOL) as assessed by the Short Form 36 Health Survey (SF\u201036) in patients undergoing antiviral therapy with pegylated interferon alfa (PEG\u2010IFNa\u20102a)\u2010based treatment in the HIDIT\u2010II trial. HIDIT\u2010II was a randomized prospective trial exploring PEG\u2010IFNa\u20102a with tenofovir disoproxil (TDF) or placebo for 96\u2009weeks in patients with compensated hepatitis delta. Surveys completed by 83 study participants before, during, and after treatments were available.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, we observed a reduced QOL of HDV patients compared with a reference population, both in physical as well as mental scores. Interestingly, PEG\u2010IFNa\u20102a treatment showed only minor impairment of the QOL during therapy. Moreover, HDV\u2010RNA clearance was not associated with relevant changes in physical or social SF\u201036 scores, whereas an improvement of fibrosis during treatment was associated with increased QOL. Overall, slight improvements of the QOL scores were observed 24\u2009weeks after the end of treatment as compared with baseline. TDF co\u2010treatment had no influence on QOL.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Overall, our findings suggest that PEG\u2010IFNa\u20102a was reasonably tolerated even over a period of 96\u2009weeks by hepatitis D patients reporting SF\u201036 questionnaires. Of note, several patients may benefit from PEG\u2010IFNa\u20102a\u2010based therapies with off\u2010treatment improvements in quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15602","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T07:36:23Z","timestamp":1684136183000},"page":"1663-1676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quality\u2010of\u2010life scores improve after 96\u2009weeks of PEG\u2010IFNa<\/scp>\u20102a treatment of hepatitis D: An analysis of the HIDIT\u2010II<\/scp> trial"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0858-6124","authenticated-orcid":false,"given":"Katja","family":"Dinkelborg","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases, and Endocrinology Hannover Medical School Hannover Germany"},{"name":"TWINCORE, Centre for Experimental and Clinical Infection Research Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kahlh\u00f6fer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases, and Endocrinology Hannover Medical School Hannover Germany"},{"name":"German Center for Infection Research (DZIF) HepNet Study\u2010House\/German Liver Foundation Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"D\u00f6rge","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases, and Endocrinology Hannover Medical School Hannover Germany"},{"name":"German Center for Infection Research (DZIF) HepNet Study\u2010House\/German Liver Foundation Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"Yurdaydin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ankara University Medical School Ankara Turkey"},{"name":"Department of Internal Medicine Koc University Medical School Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Hardtke","sequence":"additional","affiliation":[{"name":"German Center for Infection Research (DZIF) HepNet Study\u2010House\/German Liver Foundation Hannover Germany"},{"name":"Institute for Infection Research and Vaccine Development University Medical Centre Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florin Alexandru","family":"Caruntu","sequence":"additional","affiliation":[{"name":"Institutul de Boli Infectioase Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela G.","family":"Curescu","sequence":"additional","affiliation":[{"name":"Spitalul Clinic de Boli Infectioase si Timisoara 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and Endocrinology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Radu","sequence":"additional","affiliation":[{"name":"Institutul de Boli Infectioase Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa K.","family":"Celen","sequence":"additional","affiliation":[{"name":"Dicle University Medical Faculty Diyarbakir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8840-5472","authenticated-orcid":false,"given":"Ramazan","family":"Idilman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ankara University Medical School Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute for Biometry Hannover Medical School Hannover 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