{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:14:24Z","timestamp":1789802064824,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Alcohol\u2010related hepatitis (AH) <jats:italic>encompasses<\/jats:italic> a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol\u2010related liver disease (ALD) phenotypes and viral cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicentre, observational study including 916 patients with AVB falling under the next categories: AH (<jats:italic>n<\/jats:italic>\u2009=\u200999), ALD cirrhosis actively drinking (d\u2010ALD) (<jats:italic>n<\/jats:italic>\u2009=\u2009285), ALD cirrhosis abstinent from alcohol (a\u2010ALD) (<jats:italic>n<\/jats:italic>\u2009=\u2009227) and viral cirrhosis (<jats:italic>n<\/jats:italic>\u2009=\u2009305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty\u2010two days transplant\u2010free survival was worse among AH, but statistical differences were only observed between AH and d\u2010ALD groups (84 vs. 93%; <jats:italic>p<\/jats:italic>\u2009=\u20090.005), when adjusted by MELD no differences were observed between AH and the other groups. At one\u2010year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a\u2010ALD (0.48; 0.29\u20130.8, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Contrary to expected, AH patients with AVB present no worse one\u2010year survival than other patients with different alcohol\u2010related phenotypes or viral cirrhosis. Abstinence influences long\u2010term survival and could explain these counterintuitive results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15606","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T07:20:22Z","timestamp":1684135222000},"page":"1548-1557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Alcohol\u2010related liver disease phenotype impacts survival after an acute variceal bleeding episode"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0928-0427","authenticated-orcid":false,"given":"Ares","family":"Villagrasa","sequence":"first","affiliation":[{"name":"Liver Unit Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Hern\u00e1ndez\u2010Gea","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Barcelona Hepatic Hemodynamic Laboratory, Liver Unit Hospital Clinic\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, IMDIM, University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1718-2985","authenticated-orcid":false,"given":"Ramon","family":"Bataller","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory, Liver Unit Hospital Clinic\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, IMDIM, University of Barcelona  Barcelona Spain"},{"name":"Center for Liver Diseases, Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Pittsburgh Liver Research Center University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Gir\u00e1ldez","sequence":"additional","affiliation":[{"name":"UCM Digestive Diseases and CIBEREHD University Hospital Virgen del Roc\u00edo, Institute of Biomedicine of Seville (CSIC\/HUVR\/US), University of Seville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8118-1760","authenticated-orcid":false,"given":"Bogdan","family":"Procopet","sequence":"additional","affiliation":[{"name":"Regional Institute of Gastroenterology and Hepatology \u201cOctavian Fodor\u201d, Hepatology Department and \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 3rd Medical Clinic  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Amitrano","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Ospedale A Cardarelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-914X","authenticated-orcid":false,"given":"Candid","family":"Villanueva","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Department of Gastroenterology, Hospital of Santa Creu and Sant Pau Universitat Aut\u00f2noma de Barcelona, Hospital Sant Pau Biomedical Research Institute (IIB Sant Pau)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Thabut","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, AP\u2010HP. 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