{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:14:20Z","timestamp":1788884060994,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Post\u2010banding ulcer bleeding (PBUB) is an understudied complication of oesophageal varices endoscopic band ligation (EBL). This systematic review with meta\u2010analysis aimed at: (a) evaluating the incidence of PBUB in patients with cirrhosis treated with EBL in primary or secondary prophylaxis or urgent treatment for acute variceal bleeding and (b) identifying predictors of PBUB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic review of articles in English published in 2006\u20132022 using the Preferred Reporting Items for Systematic Reviews and Meta\u2010analyses guidelines. Searches were made in eight databases including Embase, PubMed and Cochrane Library. Random\u2010effects meta\u2010analysis was used to determine the incidence, mean interval and predictors of PBUB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen studies (9034 patients) were included. The incidence of PBUB was 5.5% (95% CI 4.3\u20137.1). The mean time for it to occur was 11\u2009days (95% CI 9.94\u201311.97). Model for End\u2010stage Liver Disease (MELD) score (OR 1.162, 95% CI 1.047\u20131.291) and EBL done in emergency setting (OR 4.902, 95% CI 2.99\u20138.05) independently predicted post\u2010ligation ulcer bleeding. Treatment included drugs, endoscopic procedures and transjugular intrahepatic portosystemic shunt. Refractory bleeding was treated with self\u2010expandable metallic stents or balloon tamponade. Mortality was on average 22.3% (95% CI 14.1\u201333.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with high MELD score and receiving EBL in an emergency setting are more prone to develop PBUB. Prognosis is still poor and the best therapeutic strategy to address remains to be ascertained.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15621","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T10:38:23Z","timestamp":1684924703000},"page":"1644-1653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Predictors and management of post\u2010banding ulcer bleeding in cirrhosis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"43","author":[{"given":"Maria","family":"de\u00a0Brito\u00a0Nunes","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"},{"name":"Department of Internal Medicine Hospital of Fribourg  Fribourg Switzerland"},{"name":"Graduate School for Health Sciences (GHS) University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Knecht","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Wiest","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Bosch","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4562-9016","authenticated-orcid":false,"given":"Annalisa","family":"Berzigotti","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28906"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0901512"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.04.019"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2019.06.019"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-14259"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04331.x"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000387"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470988831"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-10-5"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100363"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001618"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2018.00059"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007157"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.08.031"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001522"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.36959\/621\/604"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21857"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-019-00938-7"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002903"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43066-021-00100-z"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12538"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12847"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20593"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169884"},{"issue":"4","key":"e_1_2_14_28_1","first-page":"232","article-title":"The effect of proton pump inhibitor on healing of post\u2010esophageal variceal ligation ulcers","volume":"51","author":"Boo GB","year":"2008","journal-title":"Korean J Gastroenterol"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505059"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0472-0"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i21.2683"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014559244"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.12.022"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002907.pub2"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.03.026"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90146-9"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617704564"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910102"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12626"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011170"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.004"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.03.070"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1666861"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v6.i3.583"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05939-2"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001214"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30794"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2021.02.001"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28148"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.05.144"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T10:47:29Z","timestamp":1692355649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.15621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,24]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/liv.15621"],"URL":"https:\/\/doi.org\/10.1111\/liv.15621","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,24]]},"assertion":[{"value":"2022-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}