{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:45:10Z","timestamp":1791265510478,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["108\u20102314\u2010B\u2010182A\u2010124\u2010MY2"],"award-info":[{"award-number":["108\u20102314\u2010B\u2010182A\u2010124\u2010MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG 8D1081"],"award-info":[{"award-number":["CMRPG 8D1081"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Magnetic resonance imaging\u2010derived proton density fat fraction (MRI\u2010PDFF) is the reference standard of hepatic steatosis assessment. This study evaluates usefulness of controlled attenuation parameter (CAP) in monitoring the clinically relevant outcome by MRI\u2010PDFF for non\u2010alcoholic fatty liver disease (NAFLD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>NAFLD patients were enrolled prospectively. Instruction was given in lifestyle modifications with exercise and control of metabolic factors. MRI\u2010PDFF and CAP were performed at enrollment and follow\u2010up, with the diagnostic validity of CAP in monitoring clinically relevant outcome defined as a decline of \u226530% relative to baseline value by MRI\u2010PDFF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 75 patients (male\/female: 49\/26, mean age: 53.2) were enrolled. Baseline MRI\u2010PDFF, CAP and liver stiffness was 14.4%, 300.2\u2009dB\/m and 6.5\u2009kPa. In a median interval of 369\u2009days, thirteen (17.3%) patients achieved clinically relevant outcome with decline of 46.7\u2009dB\/m by CAP, compared with increase of 5.1 in the other patients. In multivariate analysis, clinically relevant outcome was associated with changes (\u0394) of CAP and glucose. Assessed by area under receiver operating curve, the performances of \u0394CAP in predicting clinically relevant outcome were 0.815 and 0.808, and with the specificity of &gt;90%, the \u0394CAP cutoff was \u221246\u2009dB\/m and \u221215% relative to baseline value; sensitivity was 53.8% and 46.2% with negative predictive value of 90.3% and 88.9% respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For NAFLD patients, CAP exhibited good performance in monitoring clinically relevant decline of hepatic steatosis in MRI\u2010PDFF. With the cutoffs of \u221246\u2009dB\/m or \u221215%, \u0394CAP is useful in excluding clinical relevant outcome achievement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15626","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T09:17:50Z","timestamp":1685438270000},"page":"1901-1908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Usefulness of controlled attenuation parameter in monitoring clinically relevant decline of hepatic steatosis for non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-9814","authenticated-orcid":false,"given":"Jing\u2010Houng","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Hepato\u2010Gastroenterology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital  Kaohsiung City 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