{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:59:48Z","timestamp":1779404388646,"version":"3.53.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Baveno VII consensus introduced the non\u2010invasive criteria of clinically significant portal hypertension (CSPH) using liver stiffness measurement (LSM). We evaluated the usefulness of the Baveno VII criteria to predict the risk of decompensation in patients with compensated advanced chronic liver disease (cACLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study of 1966 patients with cACLD. Patients were categorized into four groups (CSPH excluded (<jats:italic>n<\/jats:italic>\u2009=\u2009619), grey zone (low risk of CSPH (<jats:italic>n<\/jats:italic>\u2009=\u2009699), high risk of CSPH (<jats:italic>n<\/jats:italic>\u2009=\u2009207)), and CSPH included (<jats:italic>n<\/jats:italic>\u2009=\u2009441)) according to Baveno VII consensus. The risk of events was estimated using a Fine and Gray competing risk regression analysis, with liver transplantation and death as competing events. We calculated standardized hazard ratios (sHR) to assess the relative risk of decompensation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1966 patients, 178 developed decompensations over a median follow\u2010up of 3.06 (IQR: 1.03\u20136.00)\u2009years. Patients with CSPH had the highest decompensation risk, followed by the grey zone high\u2010risk group, grey zone low\u2010risk group, and those without CSPH with 3\u2010year cumulative risks of 22%, 12%, 3.3%, and 1.4% respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Compared to CSPH excluded group, CSPH included group (sHR: 8.00, 95% CI: 4.00\u201316.0), grey zone high\u2010risk group (sHR: 6.57, 95% CI: 3.16\u201313.6), grey zone low\u2010risk group (sHR: 2.15, 95% CI: 1.04\u20134.41) had significantly higher risk of decompensation (Gray's test <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Non\u2010invasive diagnosis of CSPH according to the Baveno VII criteria can stratify the risk of decompensation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15632","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T10:30:17Z","timestamp":1686220217000},"page":"1966-1974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Validation of non\u2010invasive diagnosis of CSPH in patients with compensated advanced chronic liver disease according to Baveno VII"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9418-7846","authenticated-orcid":false,"given":"Byeong Geun","family":"Song","sequence":"first","affiliation":[{"name":"Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Ji","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonseok","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6453-3450","authenticated-orcid":false,"given":"Geum\u2010Youn","family":"Gwak","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Han","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Seok","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Hyeok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Woon","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-5554","authenticated-orcid":false,"given":"Dong Hyun","family":"Sinn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60121-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.024"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.12.022"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.07.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28824"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2020.0311"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl19024"},{"issue":"3","key":"e_1_2_10_12_1","first-page":"267","article-title":"2014 KLCSG\u2010NCC Korea Practice Guideline for the Management of Hepatocellular Carcinoma","volume":"9","author":"Korean Liver Cancer Study Group (KLCSG); 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