{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:01:53Z","timestamp":1787032913223,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,9]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aims<\/jats:title>\n Hepatitis D virus (HDV) underdiagnosis remains common. We assessed the HDV screening and prevalence rates in HBsAg\u2010positive patients seen at tertiary liver centres throughout Greece as well as factors affecting HDV diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n All adult HBsAg\u2010positive patients seen within the last 5\u2009years were included. Non\u2010screened patients who visited or could be recalled to the clinics over a 6\u2010month period were prospectively tested for anti\u2010HDV.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 5079 HBsAg\u2010positive patients, 53% had anti\u2010HDV screening (41% before and 12% after study initiation). Pre\u2010study (8%\u201388%) and total screening rates (14%\u2013100%) varied widely among centres. Screening rates were associated with older age, known risk group, elevated ALT, centre location and size and period of first visit. Anti\u2010HDV prevalence was 5.8% without significant difference in patients screened before (6.1%) or after study initiation (4.7%,\n p<\/jats:italic>\n \u2009=\u20090.240). Anti\u2010HDV positivity was associated with younger age, parenteral drug use, born abroad, advanced liver disease and centre location. Overall, HDV RNA detectability rate was 71.6% being more frequent in anti\u2010HDV\u2010positive patients with elevated ALT, advanced liver disease and hepatitis B therapy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Anti\u2010HDV screening rates and recall capabilities vary widely among Greek liver clinics being higher in HBsAg\u2010positive patients of known risk group with active\/advanced liver disease seen at smaller centres, while non\u2010medical factors are also important. Anti\u2010HDV prevalence varies throughout Greece being higher in patients born abroad with younger age, parenteral drug use and advanced liver disease. Viremia is more frequently but not exclusively detected in anti\u2010HDV\u2010positive patients with elevated ALT and advanced liver disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.15638","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T06:23:58Z","timestamp":1686205438000},"page":"1879-1889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["HERACLIS\u2010HDV<\/scp>\n cohort for the factors of underdiagnosis and prevalence of hepatitis D virus infection in\n HBsAg<\/scp>\n \u2010positive patients"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3518-4060","authenticated-orcid":false,"given":"George","family":"Papatheodoridis","sequence":"first","affiliation":[{"name":"Department of Gastroenterology General Hospital of Athens \"Laiko\", Medical School of National & Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Mimidis","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine University General Hospital of Alexandroupolis Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spilios","family":"Manolakopoulos","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine General Hospital of Athens \u201cHippokratio\", Medical School of National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-8209","authenticated-orcid":false,"given":"Christos","family":"Triantos","sequence":"additional","affiliation":[{"name":"Gastroenterology Clinic University General Hospital of Patras Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3680-8194","authenticated-orcid":false,"given":"Ioannis","family":"Vlachogiannakos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology General Hospital of Athens \"Laiko\", Medical School of National & Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Veretanos","sequence":"additional","affiliation":[{"name":"Fourth Internal Medicine and Gastroenterology Department General Hospital of Athens \u201cEvangelismos\u201d Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine General Hospital of Athens \u201cHippokratio\", Medical School of National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Karatapanis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine General Hospital of Rhodes Rhodes Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Goulis","sequence":"additional","affiliation":[{"name":"Fourth Department of Internal Medicine General Hospital of Thessaloniki \u201cHippokratio\u201d, Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8118-7190","authenticated-orcid":false,"given":"Ioannis","family":"Elefsiniotis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine General and Oncology Hospital of Kifisia \u201cAgioi Anargyroi\u201d Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3645-582X","authenticated-orcid":false,"given":"Evangelos","family":"Cholongitas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology General Hospital of Athens \"Laiko\", Medical School of National & Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Sevastianos","sequence":"additional","affiliation":[{"name":"Fourth Internal Medicine and Gastroenterology Department General Hospital of Athens \u201cEvangelismos\u201d Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University General Hospital of Ioannina Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Samonakis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University General Hospital of Heraklion Crete Heraclion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Manesis","sequence":"additional","affiliation":[{"name":"Gastroenterology Clinic Euroclinic SA Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kapatais","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine General Hospital Nikaia\u2010Piraeus \u201cAgios Panteleimon\u201d & General Hospital of Western Attica \u201cAgia Varvara\u201d Piraeus Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8702-1685","authenticated-orcid":false,"given":"Nikolaos","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine General Hospital of Athens \u201cHippokratio\", Medical School of National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Ioannidou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology General Hospital of Athens \"Laiko\", Medical School of National & Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Germanidis","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine University General Hospital of Thessaloniki \u201cAHEPA\u201d Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Giannoulis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine General University Hospital of Larissa Larissa 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Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Zisimopoulos","sequence":"additional","affiliation":[{"name":"Gastroenterology Clinic University General Hospital of Patras Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mela","sequence":"additional","affiliation":[{"name":"Fourth Internal Medicine and Gastroenterology Department General Hospital of Athens \u201cEvangelismos\u201d Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kontos","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine General Hospital of Athens \u201cHippokratio\", Medical School of National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Fytili","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology General 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International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T02:45:41Z","timestamp":1691808341000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.15638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,8]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/liv.15638"],"URL":"https:\/\/doi.org\/10.1111\/liv.15638","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,8]]},"assertion":[{"value":"2023-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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