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Here, we reported that the EVs released by steatotic hepatocytes exerted a detrimental effect on pancreatic \u03b2 cells, leading to \u03b2\u2010cell apoptosis and dysfunction. The effect was profoundly attributable to an up\u2010regulation of miR\u2010126a\u20103p in the steatotic hepatocyte\u2010derived EVs. Accordingly, overexpression of miR\u2010126a\u20103p promoted, whereas inhibition of miR\u2010126a\u20103p prevented \u03b2\u2010cell apoptosis, through a mechanism related to its target gene, insulin receptor substrate\u20102. Moreover, inhibition of miR\u2010126a\u20103p by its specific antagomir was able to partially reverse the loss of \u03b2\u2010cell mass and ameliorate hyperglycaemia in diabetic mice. Thus, the findings reveal a novel pathogenic role of steatotic hepatocyte\u2010derived EVs, which mechanistically links nonalcoholic fatty liver disease to the development of diabetes.<\/jats:p>","DOI":"10.1111\/liv.15654","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T07:55:33Z","timestamp":1687247733000},"page":"2560-2570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Steatotic hepatocyte\u2010derived extracellular vesicles promote \u03b2\u2010cell apoptosis and diabetes via <scp>microRNA<\/scp>\u2010126a\u20103p"],"prefix":"10.1111","volume":"43","author":[{"given":"Qi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Fudan Institute for Metabolic Diseases, Zhongshan Hospital Fudan University  Shanghai 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