{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:37:22Z","timestamp":1791488242479,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015311","name":"Novartis Institutes for BioMedical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015311","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>A reduction in hepatic venous pressure gradient (HVPG) is the most accurate marker for assessing the severity of portal hypertension and the effectiveness of intervention treatments. This study aimed to evaluate the prognostic potential of blood\u2010based proteomic biomarkers in predicting HVPG response amongst cirrhotic patients with portal hypertension due to Hepatitis C virus (HCV) and had achieved sustained virologic response (SVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study comprised 59 patients from two cohorts. Patients underwent paired HVPG (pretreatment and after SVR), liver stiffness (LSM), and enhanced liver fibrosis scores (ELF) measurements, as well as proteomics\u2010based profiling on serum samples using SomaScan\u00ae at baseline (BL) and after SVR (EOS). Machine learning with feature selection (<jats:italic>Caret, Random Forest and RPART<\/jats:italic>) methods were performed to determine the proteins capable of classifying HVPG responders. Model performance was evaluated using AUROC (<jats:italic>pROC R package<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were stratified by a change in HVPG (EOS vs. BL) into responders (greater than 20% decline in HVPG from BL, or &lt;10\u2009mmHg at EOS with &gt;10\u2009mmHg at BL) and non\u2010responders. LSM and ELF decreased markedly after SVR but did not correlate with HVPG response. SomaScan (SomaLogic, Inc., Boulder, CO) analysis revealed a substantial shift in the peripheral proteome composition, reflected by 82 significantly differentially abundant proteins. Twelve proteins accurately distinguished responders from non\u2010responders, with an AUROC of .86, sensitivity of 83%, specificity of 83%, accuracy of 83%, PPV of 83%, and NPV of 83%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A combined non\u2010invasive soluble protein signature was identified, capable of accurately predicting HVPG response in HCV liver cirrhosis patients after achieving SVR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15657","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T04:25:58Z","timestamp":1689308758000},"page":"1984-1994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Non\u2010invasive candidate protein\u00a0signature predicts hepatic venous pressure gradient reduction in cirrhotic patients after sustained virologic response"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7108-1483","authenticated-orcid":false,"given":"Shola M.","family":"Richards","sequence":"first","affiliation":[{"name":"Novartis Institutes of Biomedical Research  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7088-3978","authenticated-orcid":false,"given":"Fang","family":"Guo","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research  East Hannover New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Zou","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research  East Hannover New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-8749","authenticated-orcid":false,"given":"Florian","family":"Nigsch","sequence":"additional","affiliation":[{"name":"Novartis Institutes of Biomedical Research  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Baiges","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory Barcelona Health Care Provider of the European Reference Network on Rare Liver  Barcelona Spain"},{"name":"CIBEREHD (Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Hep\u00e1ticas y Digestivas)  Barcelona Spain"},{"name":"Liver Unit, Hospital Cl\u00ednic, Institut de Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Departament de Medicina. 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