{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:15:57Z","timestamp":1784279757020,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied the trends in liver cancer\u2010related mortality before and during the COVID\u201019 pandemic. Quarterly age\u2010standardized mortality and quarterly percentage change (QPC) for hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) were estimated using the US national mortality database 2017\u20132021. Quarterly age\u2010standardized mortality from HCC decreased steadily with an average QPC of \u22120.4% (95% confidence interval [CI]: \u22120.6% to \u22120.2%). A decrease in hepatitis C virus and hepatitis B virus\u2010related HCC mortality of \u22122.2% (95% CI: \u22122.4% to \u22121.9%) and\u2009\u22121.1% (95% CI: \u22122.0% to \u22120.3%) was noted. In contrast, mortality for HCC from nonalcoholic fatty liver disease (3.0%, 95% CI: 2.0%\u20134.0%) and alcohol\u2010related liver disease (1.3%, 95% CI: 0.8%\u20131.9%) demonstrated a linear increase. There was a linear increase in the quarterly age\u2010standardized ICC\u2010related mortality (0.8%, 95% CI: 0.5%\u20131.0%). While ICC\u2010related mortality continued to increase, HCC\u2010related mortality tended to decline mainly due to a decline in mortality due to viral hepatitis.<\/jats:p>","DOI":"10.1111\/liv.15668","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T12:14:32Z","timestamp":1688127272000},"page":"1865-1870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Trends in mortality of liver cancer before and during the <scp>COVID<\/scp>\u201019 pandemic, 2017\u20132021"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1919-6800","authenticated-orcid":false,"given":"Donghee","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7348-8081","authenticated-orcid":false,"given":"Richie","family":"Manikat","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5335-8426","authenticated-orcid":false,"given":"George","family":"Cholankeril","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology, Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-8586","authenticated-orcid":false,"given":"Aijaz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.5688"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.05.007"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31942"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2019.06.012"},{"issue":"1","key":"e_1_2_11_8_1","article-title":"Incidence of Cholangiocarcinoma in the USA from 2001 to 2015: a US cancer statistics analysis of 50 states","volume":"11","author":"Patel N","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001151"},{"key":"e_1_2_11_10_1","unstructured":"WHO.WHO Coronavirus (COVID\u201019) Dashboard. 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