{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:43:22Z","timestamp":1778856202509,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of non\u2010alcoholic fatty liver disease (NAFLD) on morbidity and mortality has yet to be documented at the general population level. This study aimed to assess whether NAFLD was associated with morbidities and mortality and to estimate its impact on health status and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population consisted of 137\u2009206 participants from Constances cohort. Non\u2010invasive diagnosis of NAFLD and advanced fibrosis was performed using the fatty liver index and Forns index, respectively. Constances data were linked to health care and hospitalization data to identify liver\u2010related events, cardiovascular diseases (CVD), extrahepatic cancers (EHC), chronic kidney disease (CKD) and all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of NAFLD was 18.3% in subjects without other chronic liver diseases, among whom 2.7% had fibrosis. NAFLD after IPTW\u2010weighted remained associated with an increased risk of death (HR 1.26, 95% CI 1.01\u20131.57), hepatic\u2010related complications (HR 2.48, 95% CI 1.99\u20133.29), CVD (HR 1.42, 95% CI 1.30\u20131.55), EHC (HR 1.11, 95% CI 1.01\u20131.28) and CKD (HR 1.81, 95% CI 1.53\u20132.07) compared to those without chronic liver diseases risk factors (Non\u2010NAFLD). In the trend analysis over the study period of inclusion and compared to Non\u2010NAFLD, NAFLD has shown a fastest growing cause of hepatic events (HR 1.38, 95% CI 1.07\u20131.76 per year), CVD (HR 1.08, 95% CI 1.03\u20131.12), CKD (HR 1.16, 95% CI 1.07\u20131.25), and death (HR 1.39, 95% CI 1.39\u20131.50).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This large community\u2010based cohort showed that NAFLD was associated with excess morbidity and mortality and demonstrated a fastest\u2010growing trend.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15674","type":"journal-article","created":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T05:15:21Z","timestamp":1689398121000},"page":"2096-2106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The <scp>NAFLD<\/scp> burden on mortality and morbidities in general population: A community\u2010based longitudinal study 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