{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:56:34Z","timestamp":1779292594487,"version":"3.51.4"},"reference-count":58,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF15OC0016692"],"award-info":[{"award-number":["NNF15OC0016692"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Frequent binge drinking is a known contributor to alcohol\u2010related harm, but its impact on systemic and hepatic inflammation is not fully understood. We hypothesize that changes in immune markers play a central role in adverse effects of acute alcohol intake, especially in patients with early liver disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the effects of acute alcohol intoxication on inflammation\u2010related markers in hepatic and systemic venous plasma in people with alcohol\u2010related liver disease (ArLD), non\u2010alcoholic fatty liver disease (NAFLD) and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010eight participants (13 with ArLD, 15 with NAFLD and 10 healthy controls) received 2.5\u2009mL of 40% ethanol per kg body weight via a nasogastric tube. Seventy\u2010two inflammation\u2010related markers were quantified in plasma from hepatic and systemic venous blood, at baseline, 60 and 180\u2009min after intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alcohol intervention altered the levels of 31 of 72 and 14 of 72 markers in the systemic and hepatic circulation. All changes observed in the hepatic circulation were also identified in the systemic circulation after 180\u2009min. Only FGF21 and IL6 were increased after alcohol intervention, while the remaining 29 markers decreased. Differences in response to acute alcohol between the groups were observed for 8 markers, and FGF21 response was blunted in individuals with steatosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acute alcohol intoxication induced changes in multiple inflammation\u2010related markers, implicated in alcohol metabolism and hepatocellular damage. Differences identified between marker response to binge drinking in ArLD, NAFLD and healthy controls may provide important clues to disease mechanisms and potential targets for treatment.<\/jats:p><jats:p><jats:bold>Clinical trial number:<\/jats:bold> NCT03018990<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15692","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T18:31:59Z","timestamp":1692642719000},"page":"2680-2691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Binge drinking episode causes acute, specific alterations in systemic and hepatic inflammation\u2010related markers"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6433-6975","authenticated-orcid":false,"given":"Evelina","family":"Stankevic","sequence":"first","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research University of Copenhagen  Copenhagen 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