{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:00:05Z","timestamp":1780552805530,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Whether the HCV test\u2010and\u2010treat strategy impacted on the rate of new HCV infections among PLWH in Italy is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective study of PLWH in the ICONA network. At baseline, PLWH were tested for HCV\u2010Ab; HCV\u2010RNA (if HCV\u2010Ab positive) and, if positive, treated with DAA. SVR12 indicated eradication. Seroconversions and re\u2010infections were evaluated yearly in HCV\u2010Ab neg and HCV\u2010RNA neg at first screening. We estimated the following: HCV seroconversions, incidence of HCV reinfections, and access to DAA and SVR12 rates tighter with factors associated with each outcome. Data were analysed by Cox regression, Poisson regression and logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen thousand seven hundred and forty\u2010three PLWH were included; 27.3% HCV\u2010Ab positive; of these, 39.3% HCV\u2010RNA positive. HCV seroconversion incidence: .48\/100 PYFU (95% CI: .36\u2013.65); re\u2010infections incidence: 1.40\/100 PYFU (95% CI: .91\u20132.04). The risk factor for HCV re\u2010infection was young age: aIRR 1.85, 95% CI: 1.17\u20132.95) per 10\u2009years younger. 86.4% of HCV viremic in follow\u2010up started DAA. PWID vs. heterosexuals (aHR .75, 95% CI .62\u2013.90), HIV\u2010RNA &gt;50 copies\/mL (aHR .70, 95% CI .56\u2013.87), HCV genotype other than G1, G2, G3, G4 or with multiple\/missing HCV genotype and post\u2010COVID\u201019 calendar periods were associated with lower DAA access. 922\/965 (95.5%) PLWH achieved SVR12. We estimated 72% reduction of chance to achieve SVR12 in PLWH with a CD4 count &lt;200\/mm<jats:sup>3<\/jats:sup> (vs. CD4 \u2265200\/mm<jats:sup>3<\/jats:sup> aOR .18, 95% CI: .07\u2013.46). 95.5% of DAA\u2010treated individuals eradicated HCV, but they represent only 53.2% of HCV viremic PLWH and 66.4% of those in follow\u2010up. HCV\u2010RNA positivity by year decreased from 41.7% in 2017 to 11.7% in 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The screening\u2010and\u2010treat campaign implemented in Italy, even if only partially effective, resulted in a dramatic drop in HCV circulation in our cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15700","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T07:42:31Z","timestamp":1693467751000},"page":"2130-2141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Is <scp>HCV<\/scp> elimination among persons living with <scp>HIV<\/scp> feasible? Data from the <scp>NoCo<\/scp> study in the setting of the <scp>ICONA<\/scp> cohort"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0073-1789","authenticated-orcid":false,"given":"Antonella","family":"d\u2019Arminio\u00a0Monforte","sequence":"first","affiliation":[{"name":"Icona Foundation  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5899-451X","authenticated-orcid":false,"given":"Alessandro","family":"Tavelli","sequence":"additional","affiliation":[{"name":"Icona Foundation  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4965-8789","authenticated-orcid":false,"given":"Roberto","family":"Rossotti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Gagliardini","sequence":"additional","affiliation":[{"name":"Clinical and Research Infectious Diseases Department National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Saracino","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, Department of Biomedical Sciences and Human Oncology University of Bari, University Hospital Policlinico  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Lo\u00a0Caputo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Sciences University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Sala","sequence":"additional","affiliation":[{"name":"Unit of Infectious and Tropical Diseases ASST Santi Paolo e Carlo, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Quiros\u2010Roldan","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, Unit of Infectious and Tropical Diseases University of Brescia, ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mussini","sequence":"additional","affiliation":[{"name":"AOU of Modena, Clinic of Infectious Diseases University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Girardi","sequence":"additional","affiliation":[{"name":"Scientific Direction National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cozzi\u2010Lepri","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME) Institute for Global Health, UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Antinori","sequence":"additional","affiliation":[{"name":"Clinical and Research Infectious Diseases Department National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3278-7138","authenticated-orcid":false,"given":"Massimo","family":"Puoti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"},{"name":"University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the NoCo Study of the Icona cohort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.22375"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2014.07.012"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.27969"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874357901812010026"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.09.027"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1512610"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.11.007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1613512"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac273"},{"key":"e_1_2_11_11_1","unstructured":"World Health Organization.Guidelines for the screening care and treatment of persons with chronic hepatitis C infection. 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