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It has a catalytic dyad involved in remodelling of phosphatidylinositol with polyunsaturated fatty acids. Genetic variants in the\n                    <jats:italic>MBOAT7<\/jats:italic>\n                    gene have been associated with the entire spectrum of non\u2010alcoholic fatty liver (NAFLD), recently redefined as metabolic dysfunction\u2010associated fatty liver disease (MAFLD) and, lately, steatotic liver disease (SLD), and to an increasing number of extrahepatic conditions. In this review, we will (a) elucidate the molecular mechanisms by which\n                    <jats:italic>MBOAT7<\/jats:italic>\n                    loss\u2010of\u2010function predisposes to MAFLD and neurodevelopmental disorders and (b) discuss the growing number of genetic studies linking\n                    <jats:italic>MBOAT7<\/jats:italic>\n                    to hepatic and extrahepatic diseases. MBOAT7 complete loss of function causes severe changes in brain development resulting in several neurological manifestations. Lower MBOAT7 hepatic expression at both the mRNA and protein levels, due to missense nucleotide polymorphisms (SNPs) in the locus containing the\n                    <jats:italic>MBOAT7<\/jats:italic>\n                    gene, affects specifically metabolic and viral diseases in the liver from simple steatosis to hepatocellular carcinoma, and potentially COVID\u201019 disease. This body of evidence shows that phosphatidylinositol remodelling is a key factor for human health.\n                  <\/jats:p>","DOI":"10.1111\/liv.15706","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:17:29Z","timestamp":1692677849000},"page":"2351-2364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["<scp>MBOAT7<\/scp>\n                    in liver and extrahepatic diseases"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4957-9493","authenticated-orcid":false,"given":"Andrea","family":"Caddeo","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Unit of Oncology and Molecular Pathology University of Cagliari  Cagliari 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