{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:19:38Z","timestamp":1789161578281,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The efficacy of transient elastography (TE) in the differential diagnosis between porto\u2010sinusoidal vascular disease (PSVD) and compensated cirrhosis has not been sufficiently studied. We aimed to investigate the diagnostic performance of TE and identify histological lesions associated with liver stiffness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study including patients with PSVD and cirrhosis (Child\u2010Turcotte\u2010Pugh class A) and healthy subjects. Both the PSVD and cirrhotic patients had at least one sign of PH. The area under the receiver operating characteristic curve (AUROC) was used for differentiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010two patients with PSVD (median age: 53\u2009years, 33% male), 100 patients with compensated cirrhosis and 101 healthy subjects were included. The median TE\u2010LSM in the PSVD patients (10.0 [7.0\u201313.0]\u2009kPa) was significantly lower than that in the cirrhotic patients (21.0 [15.0\u201328.0]\u2009kPa, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) but was significantly higher than that in the healthy subjects (5.1 [4.6\u20136.0]\u2009kPa, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The AUROCs of TE\u2010LSM for the discrimination of PSVD from the cirrhosis and healthy subjects were 0.886 (95% CI: 0.833\u20130.928) and 0.913 (95% CI: 0.864\u20130.949), respectively. The sensitivity and specificity to discriminate PSVD from compensated cirrhosis were 78.3% and 82.0%, respectively, at a cut\u2010off of 13.6\u2009kPa. Furthermore, portal fibrosis and aberrant cytokeratin 7 expression of centrilobular hepatocytes were significantly associated with higher TE\u2010LSM (\u226510.0\u2009kPa).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TE\u2010LSM can be used to differentiate PSVD from compensated cirrhosis. Pathological features in association with increased liver stiffness are identified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15709","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T07:05:19Z","timestamp":1692860719000},"page":"2513-2522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Diagnostic performance of transient elastography in differentiation between porto\u2010sinusoidal vascular liver disease and compensated cirrhosis"],"prefix":"10.1111","volume":"43","author":[{"given":"Guanhua","family":"Zhang","sequence":"first","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Digestive Diseases Beijing Friendship Hospital, Capital Medical University  Beijing 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