{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:18Z","timestamp":1787015718205,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002647","name":"Sungkyunkwan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Given that the majority of colorectal cancers (CRCs) develop from high\u2010risk adenomas, identifying risk factors for high\u2010risk adenomas is important. The relationship between metabolic dysfunction\u2010associated fatty liver disease (MAFLD) and the risk of colorectal adenoma in young adults remains unclear. We aimed to evaluate this relationship in adults &lt;50 (younger) and\u2009\u226550 (older)\u2009years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 184\u2009792 Korean adults (80% &lt;50\u2009years of age) who all underwent liver ultrasound and colonoscopy. Participants were grouped into those with and without MAFLD and classified by adenoma presence into no adenoma, low\u2010risk adenoma, or high\u2010risk adenoma (defined as \u22653 adenomas, any \u226510\u2009mm, or adenoma with high\u2010grade dysplasia\/villous features).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of low\u2010 and high\u2010risk adenomas among young and older adults was 9.6% and 0.8% and 22.3% and 4.8%, respectively. MAFLD was associated with an increased prevalence of low\u2010 and high\u2010risk adenomas in young and older adults. Young adults with MAFLD had a 1.30 (95% CIs 1.26\u20131.35) and 1.40 (1.23\u20131.59) times higher prevalence of low\u2010 and high\u2010risk adenomas, respectively, compared to those without MAFLD. These associations were consistent even in lean adults (BMI\u2009&lt;\u200923\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and those without a family history of CRC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MAFLD is associated with an increased prevalence of low\u2010 and high\u2010risk adenomas in Korean adults, regardless of age or obesity status. Whether reducing metabolic risk factors, such as MAFLD, reduces the risk of precancerous lesions and ultimately reduces the risk of early\u2010onset CRC requires further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15738","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T03:54:39Z","timestamp":1695354879000},"page":"2548-2559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Metabolic\u2010associated fatty liver disease is associated with colorectal adenomas in young and older Korean adults"],"prefix":"10.1111","volume":"43","author":[{"given":"Jiwon","family":"Chang","sequence":"first","affiliation":[{"name":"Total Healthcare Center Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6945-9050","authenticated-orcid":false,"given":"Yoosoo","family":"Chang","sequence":"additional","affiliation":[{"name":"Center for Cohort Studies Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"},{"name":"Department of Occupational and Environmental Medicine Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"},{"name":"Department of Clinical Research Design &amp; Evaluation, Samsung Advanced Institute for Health Sciences &amp; Technology Sungkyunkwan University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoosun","family":"Cho","sequence":"additional","affiliation":[{"name":"Total Healthcare Center Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"},{"name":"Center for Cohort Studies Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Suk","family":"Jung","sequence":"additional","affiliation":[{"name":"Total Healthcare Center Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"},{"name":"Department of Clinical Research Design &amp; Evaluation, Samsung Advanced Institute for Health Sciences &amp; Technology Sungkyunkwan University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Il","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, School of Medicine Kangbuk Samsung Hospital, Sungkyunkwan University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Kyung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, 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