{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:41:32Z","timestamp":1767897692691,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023181","name":"Agencja Bada\u0144 Medycznych","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>The aim of this study was to assess the effect of treatment with sofosbuvir\/velpatasvir (SOF\/VEL) on the health\u2010related quality of life (HRQL) of children with chronic hepatitis C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the non\u2010commercial, non\u2010randomized, open\u2010label PANDAA\u2010PED study, 50 children aged 6\u201318\u2009years with chronic hepatitis C were treated with a fixed dose of SOF\/VEL. All patients achieved sustained virologic response 12\u2009weeks after the end of treatment (SVR12). Evaluation of HRQL was performed twice: at baseline (before the treatment) and during the SVR12 analysis using the KIDSCREEN\u201027 questionnaires, which included 5 dimensions of HRQL, for child self\u2010reporting and parent proxy reporting. The normal range for the population was set to <jats:italic>T<\/jats:italic> values of 50\u2009\u00b1\u200910 points. Child\u2013parent agreement was analysed using the intra\u2010class correlation coefficient (ICC) and Bland\u2013Altman test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean <jats:italic>T<\/jats:italic> values were within the normal range for all dimensions, both before and after treatment. There was a significant improvement in physical well\u2010being based on the children's self\u2010assessment (from 48.53 to 51.21, <jats:italic>p<\/jats:italic>\u2009=\u2009.03). In addition, a trend towards better scores in the \u2018social support &amp; peers\u2019 part of the parent proxy evaluation (from 45.98 to 48.66, <jats:italic>p<\/jats:italic>\u2009=\u2009.06) was noticed. After the treatment, the proportion of children self\u2010assessing their physical well\u2010being as below normal significantly decreased from 17% to 5% (<jats:italic>p<\/jats:italic>\u2009=\u2009.007). HRQL scores were not associated with patients' sex, but in most cases, younger age correlated with better HRQL. Evaluation of the ICC for child self\u2010reports versus parent proxy reports revealed poor to moderate agreement for most single measures. Bland\u2013Altman analysis showed that in all dimensions, both before and after treatment, the limits of agreement (LoAs) exceeded \u00b15 points (half of the SD and considered a maximum allowed difference).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A significant proportion of children with chronic hepatitis C have decreased HRQL in all dimensions, but effective treatment with SOF\/VEL leads to an improvement in some areas of well\u2010being. As the effect of HCV on HRQL is more pronounced in older patients, treatment of younger children should be indicated to prevent them from experiencing decreased HRQL due to ongoing HCV infection in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15744","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T06:49:17Z","timestamp":1695365357000},"page":"93-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Health\u2010related quality of life in patients aged 6\u201318\u2009years with chronic hepatitis C treated with sofosbuvir\/velpatasvir"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7783-6904","authenticated-orcid":false,"given":"Maria","family":"Pokorska\u2010\u015apiewak","sequence":"first","affiliation":[{"name":"Department of Children's Infectious Diseases Medical University of Warsaw  Warsaw Poland"},{"name":"Department of Pediatric Infectious Diseases Regional Hospital of Infectious Diseases in Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Talarek","sequence":"additional","affiliation":[{"name":"Department of Children's Infectious Diseases Medical University of Warsaw  Warsaw Poland"},{"name":"Department of Pediatric Infectious Diseases Regional Hospital of Infectious Diseases in Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Aniszewska","sequence":"additional","affiliation":[{"name":"Department of Children's Infectious Diseases Medical University of Warsaw  Warsaw Poland"},{"name":"Department of Pediatric Infectious Diseases Regional Hospital of Infectious Diseases in Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Pluta","sequence":"additional","affiliation":[{"name":"Department of Children's Infectious Diseases Medical University of Warsaw  Warsaw Poland"},{"name":"Department of Pediatric Infectious Diseases Regional Hospital of Infectious Diseases in Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Dobrzeniecka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases Regional Hospital of Infectious Diseases in Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Marczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Children's Infectious Diseases Medical University of Warsaw  Warsaw Poland"},{"name":"Department of Pediatric Infectious Diseases Regional Hospital of Infectious Diseases in Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-9823","authenticated-orcid":false,"given":"Giuseppe","family":"Indolfi","sequence":"additional","affiliation":[{"name":"Department of Neurofarba Meyer Children's University of Florence  Florence Italy"},{"name":"Meyer Children's Hospital IRCCS  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30385-1"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13005"},{"key":"e_1_2_13_4_1","unstructured":"Centers for Disease Control and Prevention. 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