{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:31:41Z","timestamp":1790857901047,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Treatment for chronic hepatitis C virus (HCV) infections changed dramatically in the last decade. We assessed changes in the prevalence of replicating HCV infection, treatment uptake and liver\u2010related morbidity and mortality in persons with HIV (PWH) and hepatitis C in the Swiss HIV cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included all cohort participants between 2002 and 2021. We assessed yearly prevalence of replicating HCV infection, overall and liver\u2010related mortality, as well as the yearly incidence of liver\u2010related events in persons with at least one documented positive HCV\u2010RNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 14\u2009652 participants under follow\u2010up, 2294 had at least one positive HCV\u2010RNA measurement. Of those, 1316 (57%) ever received an HCV treatment. Treatment uptake increased from 8.1% in 2002 to a maximum of 32.6% in 2016. Overall, prevalence of replicating HCV infection declined from 16.5% in 2004 to 1.3% in 2021. HCV prevalence declined from 63.2% to 7.1% in persons who inject drugs, and from 4.1% to 0.6% in men who have sex with men. Among the 2294 persons with replicating HCV infection, overall mortality declined from a maximum of 3.3 per 100 patient\u2010years (PY) to 1.1 per 100 PY, and incidence of liver\u2010related events decreased from 1.4\/100 PY to 0.2\/100 PY.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The introduction of DAA therapy was associated with a more than 10\u2010fold reduction in prevalence of replicating HCV infection in PWH, approaching the estimates in the general population. Overall mortality and liver\u2010related events declined substantially in persons living with HIV and hepatitis C.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15754","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T12:05:14Z","timestamp":1697630714000},"page":"169-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Long\u2010term trends in hepatitis C prevalence, treatment uptake and liver\u2010related events in the Swiss <scp>HIV<\/scp> Cohort Study"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2778-2212","authenticated-orcid":false,"given":"Lukas","family":"Baumann","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique L.","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich University of Zurich  Zurich Switzerland"},{"name":"Institute of Medical Virology University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0933-7833","authenticated-orcid":false,"given":"Matthias","family":"Cavassini","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Lausanne University Hospital University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Stoeckle","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enos","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Ente Ospedaliero Cantonale, Lugano University of Geneva and University of Southern Switzerland  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Schmid","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Cantonal Hospital St. Gallen  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Calmy","sequence":"additional","affiliation":[{"name":"HIV\/AIDS Unit, Division of Infectious Diseases Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Haerry","sequence":"additional","affiliation":[{"name":"Chair Positive Council  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"B\u00e9guelin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"},{"name":"Division of Infectious Diseases Regional Hospital Biel  Biel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph A.","family":"Fux","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Infection Prevention Cantonal Hospital Aarau  Aarau Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5278-8763","authenticated-orcid":false,"given":"Gilles","family":"Wandeler","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1402-974X","authenticated-orcid":false,"given":"Bernard","family":"Surial","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Inselspital, Bern University Hospital University of 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