{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:30:25Z","timestamp":1790281825424,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["DNRF141"],"award-info":[{"award-number":["DNRF141"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Patients with metabolic dysfunction\u2010associated steatotic liver disease (MASLD) are often comorbid and stigmatized. This can negatively affect quality of life (QOL). Other studies have primarily used the Chronic Liver Disease Questionnaire (CLDQ), which focuses on liver\u2010related symptoms, to characterize QOL, but most MASLD patients have only mild liver disease, and CLDQ might overlook QOL issues pertaining to them. We aimed to determine the impact of metabolic dysfunction\u2010associated steatohepatitis (MASH) on QOL in obese patients using a 136\u2010item generic QOL questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included participants with BMI\u2009\u2265\u200935\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      who all fully answered the sickness impact profile (SIP, range 0\u2013100, normal\u2009=\u20093.4, 100\u2009=\u2009worst) and had a liver biopsy to diagnose MASLD. Sociodemographics, comorbidity and biometric data were obtained from all participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 176 (mean age 45.9\u2009years, 70% female, 12.6\u2009years of education), 132 had no\u2010MASH and 44 MASH. On stepwise multivariable regression analysis, divorce (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.011), unemployment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.003) and hepatic steatosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01) were associated with poor overall QOL. No other somatic comorbidity was associated. MASH patients more frequently than no\u2010MASH reported physical discomfort (48% vs. 30%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.04), inability to do daily activities (29% vs. 54%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.006) and attention problems (32% vs. 57%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MASLD severity was the only somatic determinant of QOL in patients with obesity in this cohort, and a large fraction reported debilitating symptoms. Patients and caregivers should consider the limitations this poses when planning interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15761","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T02:35:32Z","timestamp":1698719732000},"page":"191-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Steatotic liver disease is the most important somatic determinant of quality of life in patients with obesity: A cross\u2010sectional study"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8964-0650","authenticated-orcid":false,"given":"Charlotte Wilhelmina","family":"Wernberg","sequence":"first","affiliation":[{"name":"Liver Research Group, Department of Gastroenterology and Hepatology University Hospital of South Denmark  Esbjerg Denmark"},{"name":"ATLAS Center for Functional Genomics and Tissue Plasticity University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads Fallesen","family":"Kjer","sequence":"additional","affiliation":[{"name":"Liver Research Group, Department of Gastroenterology and Hepatology University Hospital of South Denmark  Esbjerg Denmark"},{"name":"OPEN Open Patient Data Explorative Network  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5754-8235","authenticated-orcid":false,"given":"Lea Ladegaard","family":"Gr\u00f8nkj\u00e6r","sequence":"additional","affiliation":[{"name":"Liver Research Group, Department of Gastroenterology and Hepatology University Hospital of South Denmark  Esbjerg Denmark"},{"name":"OPEN Open Patient Data Explorative Network  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte Gade","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Liver Research Group, Department of Gastroenterology and Hepatology University Hospital of South Denmark  Esbjerg Denmark"},{"name":"OPEN Open Patient Data Explorative Network  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0586-8549","authenticated-orcid":false,"given":"Mette Munk","family":"Lauridsen","sequence":"additional","affiliation":[{"name":"Liver Research Group, Department of Gastroenterology and Hepatology University Hospital of South Denmark  Esbjerg Denmark"},{"name":"ATLAS Center for Functional Genomics and Tissue Plasticity University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"key":"e_1_2_19_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-48382-5_1"},{"key":"e_1_2_19_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i28.9330"},{"key":"e_1_2_19_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16183415"},{"key":"e_1_2_19_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_2_19_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2017.08.007"},{"key":"e_1_2_19_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091575"},{"key":"e_1_2_19_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21327"},{"key":"e_1_2_19_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.205088"},{"key":"e_1_2_19_10_1","first-page":"10","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and non\u2010alcoholic steatohepatitis (NASH): a systematic review","volume":"1097","author":"Younossi Z","year":"2023","journal-title":"Hepatology"},{"key":"e_1_2_19_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1909301"},{"key":"e_1_2_19_12_1","doi-asserted-by":"publisher","DOI":"10.2991\/jegh.k.191028.001"},{"key":"e_1_2_19_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-036663"},{"key":"e_1_2_19_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41687-018-0052-7"},{"key":"e_1_2_19_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03426.x"},{"key":"e_1_2_19_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22868"},{"key":"e_1_2_19_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.12.016"},{"key":"e_1_2_19_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-016-0420-z"},{"key":"e_1_2_19_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100525"},{"key":"e_1_2_19_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32620"},{"key":"e_1_2_19_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1555"},{"key":"e_1_2_19_22_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.119790"},{"key":"e_1_2_19_23_1","volume-title":"Medicinsk Kompendium","author":"Muckadell OBS","year":"2019"},{"key":"e_1_2_19_24_1","first-page":"1950","article-title":"De 'sickness impact profile'; 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