{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T14:09:04Z","timestamp":1773497344293,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>To measure the impact of socio\u2010economic environment on the incidence of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study used data from the French Network of Cancer Registries (FRANCIM) between 2006 and 2016. Classification of patients into HCC and iCCA was performed according to the topographical and morphological codes of the 3rd edition of the International Classification of Diseases for Oncology. Patient addresses were geolocalized and assigned to an IRIS, the smallest French geographic unit. Socio\u2010economic environment was assessed by the European Deprivation Index (EDI). Sex\u2010 and age\u2010standardized incidence rates with 95% confidence intervals (CI) were estimated per 100\u2009000 inhabitants, by national quintiles, for each IRIS, sex and age group. Quintile 1 (Q1) characterized the most affluent areas. A Poisson regression was performed to model the impact of deprivation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 22\u2009249 cases (79.64% HCC, 16.97% iCCA). Incidence rates were 11.46 and 2.39 per 100\u2009000 person\u2010years for HCC and iCCA, respectively. There was an over\u2010incidence of HCC in quintiles 2, 3, 4 and 5 compared to quintile 1: Q1 10.28 [9.9\u201310.66] per 100\u2009000 person\u2010years, Q2 11.43 [10.48\u201312.47] (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001), Q3 11.81 [10.82\u201312.89] (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001), Q4 12.26 [11.25\u201313.37] (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and Q5 11.53 [10.57\u201312.57] (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). By contrast, there was no difference for iCCa. Deprivation was significantly associated with HCC in men (<jats:italic>p<\/jats:italic>\u2009=\u2009.0018) and women (<jats:italic>p<\/jats:italic>\u2009=\u2009.0009), but not with iCCA (<jats:italic>p<\/jats:italic>\u2009=\u2009.7407).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of HCC is related to socio\u2010economic environment, unlike iCCA. HCC and iCCA should be studied separately in epidemiological studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15784","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T01:25:22Z","timestamp":1701134722000},"page":"446-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of socio\u2010economic environment on incidence of primary liver cancer in France between 2006 and 2016"],"prefix":"10.1111","volume":"44","author":[{"given":"Bertille","family":"Comoz","sequence":"first","affiliation":[{"name":"Service d'h\u00e9pato\u2010gastroent\u00e9rologie CHU de Caen  Caen France"},{"name":"ANTICIPE U1086 INSERM\u2010UCN, Universit\u00e9 de Caen Normandie UNICAEN, Centre Fran\u00e7ois Baclesse  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5254-2464","authenticated-orcid":false,"given":"Isabelle","family":"Ollivier\u2010Hourmand","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9pato\u2010gastroent\u00e9rologie CHU de Caen  Caen France"},{"name":"ANTICIPE U1086 INSERM\u2010UCN, Universit\u00e9 de Caen Normandie UNICAEN, Centre Fran\u00e7ois Baclesse  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9070-1027","authenticated-orcid":false,"given":"Anne\u2010Marie","family":"Bouvier","sequence":"additional","affiliation":[{"name":"Registre Bourguignon des Cancers digestifs INSERM UMR 1231, UFR Sant\u00e9 de Bourgogne  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Baptiste","family":"Nousbaum","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9pato\u2010gastroent\u00e9rologie CHU de Brest  Brest France"},{"name":"Registre des Cancers digestifs du Finist\u00e8re, EA 7479 SPURBO Universit\u00e9 de Bretagne Occidentale  Brest France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8663-5714","authenticated-orcid":false,"given":"Thi Thu Nga","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9pato\u2010gastroent\u00e9rologie CHU de Caen  Caen France"},{"name":"ANTICIPE U1086 INSERM\u2010UCN, Universit\u00e9 de Caen Normandie UNICAEN, Centre Fran\u00e7ois Baclesse  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Launoy","sequence":"additional","affiliation":[{"name":"ANTICIPE U1086 INSERM\u2010UCN, Universit\u00e9 de Caen Normandie UNICAEN, Centre Fran\u00e7ois Baclesse  Caen France"},{"name":"Registre des Cancers digestifs du Calvados CHU de Caen  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Bouvier","sequence":"additional","affiliation":[{"name":"ANTICIPE U1086 INSERM\u2010UCN, Universit\u00e9 de Caen Normandie UNICAEN, Centre Fran\u00e7ois Baclesse  Caen France"},{"name":"Registre des Cancers digestifs du Calvados CHU de Caen  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9phine","family":"Bryere","sequence":"additional","affiliation":[{"name":"ANTICIPE U1086 INSERM\u2010UCN, Universit\u00e9 de Caen Normandie UNICAEN, Centre Fran\u00e7ois Baclesse  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_13_3_1","first-page":"372","volume-title":"Volume 1\u2014Tumeurs solides","author":"Defossey G","year":"2019"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.08.021"},{"key":"e_1_2_13_5_1","volume-title":"ICD\u2010O. 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