{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:31:17Z","timestamp":1793309477052,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K08 DK132312"],"award-info":[{"award-number":["K08 DK132312"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Ferritin has been investigated as a biomarker for liver fibrosis and iron in patients with metabolic dysfunction\u2010associated steatotic liver disease (MASLD). However, whether metabolic hyperferritinaemia predicts progression of liver disease remains unknown. In this study, we sought to understand associations between hyperferritinaemia and (1) adverse clinical outcomes and (2) common genetic variants related to iron metabolism and liver fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective analysis of adults with MASLD seen at the University of Michigan Health System, where MASLD was defined by hepatic steatosis on imaging, biopsy or vibration\u2010controlled transient elastography, plus metabolic risk factors in the absence of chronic liver diseases other than hemochromatosis. The primary predictor was serum ferritin level, which was dichotomized based on a cut\u2010off of 300 or 450\u2009mcg\/L for women or men. Primary outcomes included (1) incident cirrhosis, liver\u2010related events, congestive heart failure (CHF), and mortality and (2) distribution of common genetic variants associated with hepatic fibrosis and hereditary hemochromatosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 7333 patients with MASLD, 1468 (20%) had elevated ferritin. In multivariate analysis, ferritinaemia was associated with increased mortality (HR 1.68 [1.35\u20132.09],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and incident liver\u2010related events (HR 1.92 [1.11\u20133.32],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.019). Furthermore, elevated ferritin was associated with carriage of cirrhosis\u2010promoting alleles including\n                      <jats:italic>PNPLA3<\/jats:italic>\n                      \u2010rs738409\u2010G allele (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0068) and\n                      <jats:italic>TM6SF2<\/jats:italic>\n                      \u2010rs58542926\u2010T allele (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0083) but not with common\n                      <jats:italic>HFE<\/jats:italic>\n                      mutations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In MASLD patients, metabolic hyperferritinaemia was associated with increased mortality and higher incidence of liver\u2010related events, and cirrhosis\u2010promoting alleles but not with iron overload\u2010promoting\n                      <jats:italic>HFE<\/jats:italic>\n                      mutations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15787","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T18:42:14Z","timestamp":1700160134000},"page":"389-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Associations between metabolic hyperferritinaemia, fibrosis\u2010promoting alleles and clinical outcomes in steatotic liver disease"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0871-9963","authenticated-orcid":false,"given":"Deepika","family":"Suresh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Michigan  Ann Arbor Michigan 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Gastroenterology and Hepatology, Department of Internal Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000520"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"9","article-title":"Non alcoholic fatty liver disease and metabolic syndrome","volume":"13","author":"Paschos P","year":"2009","journal-title":"Hippokratia"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20734"},{"issue":"1","key":"e_1_2_9_5_1","first-page":"S102","article-title":"Predictors of metabolic\u2010associated fatty liver disease (MAFLD) in adults: a population\u2010based study in northeastern Iran","volume":"14","author":"Taheri E","year":"2021","journal-title":"Gastroenterol Hepatol Bed 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