{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:32:48Z","timestamp":1779258768217,"version":"3.51.4"},"reference-count":182,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000866","name":"Cardiff University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012068","name":"Health and Care Research Wales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012068","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is a growing public health threat and becoming the leading cause of liver transplantation. Nevertheless, no approved specific treatment is currently available for NAFLD. The pathogenesis of NAFLD is multifaceted and not yet fully understood. Accumulating evidence suggests a significant role of the complement system in the development and progression of NAFLD. Here, we provide an overview of the complement system, incorporating the novel concept of complosome, and summarise the up\u2010to\u2010date evidence elucidating the association between complement dysregulation and the pathogenesis of NAFLD. In this process, the extracellular complement system is activated through various pathways, thereby directly contributing to, or working together with other immune cells in the disease development and progression. We also introduce the complosome and assess the evidence that implicates its potential influence in NAFLD through its direct impact on hepatocytes or non\u2010parenchymal liver cells. Additionally, we expound upon how complement system and the complosome may exert their effects in relation with hepatic zonation in NAFLD. Furthermore, we discuss the potential therapeutic implications of targeting the complement system, extracellularly and intracellularly, for NAFLD treatment. Finally, we present future perspectives towards a better understanding of the complement system's contribution to NAFLD.<\/jats:p>","DOI":"10.1111\/liv.15796","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T01:17:11Z","timestamp":1701134231000},"page":"316-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["From complement to complosome in non\u2010alcoholic fatty liver disease: When location matters"],"prefix":"10.1111","volume":"44","author":[{"given":"Van\u2010Dien","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine Cardiff University  Cardiff UK"},{"name":"Systems Immunity Research Institute Cardiff University  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy R.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine Cardiff University  Cardiff UK"},{"name":"Systems Immunity Research Institute Cardiff University  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1743-1291","authenticated-orcid":false,"given":"You","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine Cardiff University  Cardiff UK"},{"name":"Systems Immunity Research Institute Cardiff University  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2022.03.010"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.12.002"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1519"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0088-6"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.05.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322786"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28785"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0104-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020117-043617"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1017467"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1284944"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.653293"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0168-x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13135"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00704-1"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202250042"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00262"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1923"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00257"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3858"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.70"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203487"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02434.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.20372"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.5.838"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.01.009"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.09.006"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.11.007"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12275"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2015.02.027"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0700"},{"issue":"5","key":"e_1_2_11_34_1","first-page":"333","article-title":"Levels of acylation stimulating protein in obese women before and after moderate weight loss","volume":"15","author":"Sniderman AD","year":"1991","journal-title":"Int J Obes (Lond)"},{"issue":"9","key":"e_1_2_11_35_1","first-page":"604","article-title":"Response of plasma ASP to a prolonged fast","volume":"19","author":"Cianflone K","year":"1995","journal-title":"Int J Obes Relat Metab Disord"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574887112666171128134552"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.2.570"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02260.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2003.100"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-0021-6"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.03.012"},{"issue":"5","key":"e_1_2_11_42_1","first-page":"775","article-title":"Determination of reference intervals for serum complement C3 and C4 levels in Chinese Han ethnic males","volume":"60","author":"Qin X","year":"2014","journal-title":"Clin Lab"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.3.505"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803543"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.11.069"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(05)70010-8"},{"issue":"2","key":"e_1_2_11_47_1","first-page":"101","article-title":"Increased level of the complement C3 protein in endogenous hypertriglyceridemia","volume":"8","author":"Uza G","year":"1982","journal-title":"J Clin Lab Immunol"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.03.007"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000014079.98335.72"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00590.2007"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.20158"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.07.008"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6368780"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.03.017"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjs032"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ac8e36"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.731141"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.03.001"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.07.031"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12952"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.747"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030374"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.4.2479"},{"issue":"8","key":"e_1_2_11_64_1","first-page":"2304","article-title":"A complement\u2010dependent balance between hepatic ischemia\/reperfusion injury and liver regeneration in mice","volume":"119","author":"He SQ","year":"2009","journal-title":"J Clin Investig"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01258-3"},{"issue":"1","key":"e_1_2_11_66_1","first-page":"79","article-title":"Complement component 3 as a surrogate Hallmark for metabolic abnormalities in patients with chronic hepatitis C","volume":"49","author":"Himoto T","year":"2019","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3524842"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00917-13"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-2-51"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200405000-00002"},{"issue":"5","key":"e_1_2_11_71_1","first-page":"333","article-title":"The complement system in liver diseases","volume":"3","author":"Qin X","year":"2006","journal-title":"Cell Mol Immunol"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02958.x"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2014.09.004"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2002.5267"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.04.041"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.01.053"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0175-2"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00334.2017"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102534"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23279"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122026"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12798"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504172"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-051218"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12093"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43657-021-00023-0"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108132"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14106"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495215"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23228"},{"issue":"5","key":"e_1_2_11_91_1","first-page":"6852","article-title":"High fish oil diet promotes liver inflammation and activates the complement system","volume":"17","author":"Jin H","year":"2018","journal-title":"Mol Med Rep"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5398-4"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2016.07.014"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74617-5"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0323"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2019-00034"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3920196"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0009"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34275"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110518"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4652(200011)185:2<280::AID-JCP13>3.0.CO;2-L"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.6.781"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.09.008"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40838.x"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50290"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110053"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1054159"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0082-x"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1159\/000518407"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0210-2"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.11.010"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2009.139"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300038"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2499"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070166"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1403068"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.03.005"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10143157"},{"issue":"1","key":"e_1_2_11_119_1","first-page":"76","article-title":"Non\u2010alcoholic fatty liver disease: growing burden, adverse outcomes and associations","volume":"8","author":"Kumar R","year":"2020","journal-title":"J Clin Transl Hepatol"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1599"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1789"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2020.1810020"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32662"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190395"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5275"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad1210"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abf2489"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.04.008"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.018"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1683-1"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.769242"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-20-0787"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900276"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218338"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.02.006"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2012.03561.x"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2021.04.005"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.05.033"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-022-00534-7"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100856R"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5249-09.2010"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2120083119"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901007R"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256070"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao4555"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.164"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00493"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110851"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.05.024"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2683"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06706-z"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15238"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.15698\/mic2020.04.712"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016287"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.02.019"},{"key":"e_1_2_11_156_1","first-page":"III","article-title":"Cooperation of liver cells in health and disease","volume":"161","author":"Kmiec Z","year":"2001","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071813-105336"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1580515"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9571-1"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9635-2"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02138"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21344"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00184.2004"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.07.006"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.09.005"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.016"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201546131"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2012.45"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-014-1170-1"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0134-x"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.09.003"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90277-4"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2019.11.003"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.01.016"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20842"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2015.10.011"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21065"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1373-2"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.07.030"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4657"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-220582"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abg0833"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.04.029"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T08:17:56Z","timestamp":1719303476000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.15796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":182,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/liv.15796"],"URL":"https:\/\/doi.org\/10.1111\/liv.15796","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,27]]},"assertion":[{"value":"2023-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}