{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:32:12Z","timestamp":1769859132945,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The objective of this study was to assess the impact of the COVID\u201019 pandemic and direct\u2010acting antiviral (DAA) agents on mortality related to chronic liver diseases (CLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Age\u2010standardized mortality rates were computed based on CLD as the underlying cause of death (UCOD) and as any mention in death certificates (multiple causes of death\u2010MCOD). Time trends in age\u2010standardized mortality rates were investigated using generalized estimation equation models. Additionally, we conducted age, period, and birth cohort (APC) analyses on CLD\u2010related mortality associated with alcohol and hepatitis C virus (HCV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2008 and 2021, among residents in the Veneto region (Northeastern Italy) aged \u226535\u2009years, there were 20\u2009409 deaths based on the UCOD and 30\u2009069 deaths based on MCOD from all CLD. We observed a 4% annual decline in age\u2010standardized MCOD\u2010based mortality throughout 2008\u20132021, with minor peaks corresponding to COVID\u201019 epidemic waves. Starting in 2016, the decline in HCV\u2010related mortality accelerated further (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). A peak in HCV\u2010related mortality in the 1963\u20131967 birth cohort was observed, which levelled off by the end of the study period. Mortality related to alcoholic liver disease declined at a slower pace, becoming the most common aetiology mentioned in death certificates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study demonstrates a significant decrease in HCV\u2010related mortality at the population level in Italy with the introduction of DAAs. Continuous monitoring of MCOD data is warranted to determine if this favourable trend will continue. Further studies utilizing additional health records are needed to clarify the role of other CLD etiologies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15798","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T11:04:49Z","timestamp":1701342289000},"page":"559-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mortality related to <scp>HCV<\/scp> and other chronic liver diseases in Veneto (Italy), 2008\u20132021: Changes in trends and age\u2010period\u2010cohort effects"],"prefix":"10.1111","volume":"44","author":[{"given":"Veronica","family":"Casotto","sequence":"first","affiliation":[{"name":"Epidemiological Department Azienda Zero  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio Barbiellini","family":"Amidei","sequence":"additional","affiliation":[{"name":"Epidemiological Department Azienda Zero  Padova 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