{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T17:39:09Z","timestamp":1775324349151,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Although non\u2010alcoholic fatty liver disease (NAFLD) is becoming a leading cause of hepatocellular carcinoma (HCC), HCC risk in non\u2010cirrhotic NAFLD received little attention. We aimed to develop and validate an HCC risk prediction model for non\u2010cirrhotic NAFLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A nationwide cohort of non\u2010cirrhotic NAFLD patients in Korea was recruited to develop a risk prediction model and validate it internally (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009409\u2009088). A model using a simplified point system was developed by Cox proportional hazard model. K\u2010fold cross\u2010validation assessed the accuracy, discrimination and calibration. The model was validated externally using a hospital cohort from Asan Medical Center (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098721).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>An 11\u2010point HCC risk prediction model for non\u2010cirrhotic NAFLD was developed using six independent factors of age, sex, diabetes, obesity, serum alanine aminotransferase level and gamma\u2010glutamyl transferase level (c\u2010index 0.75). The average area under receiver operating curves (AUROCs) of the model was 0.72 at 5\u2009years and 0.75 at 10\u2009years. In the external validation cohort, the AUROCs were 0.79 [95% confidence interval [CI], 0.59\u20130.95] at 5\u2009years and 0.84 (95% CI, 0.73\u20130.94) at 10\u2009years. The calibration plots showed the expected risks corresponded well with the observed risks. Risk stratification categorized patients into the low (score 0\u20136), moderate (7, 8) and high (9\u201311; estimated incidence rate\u2009&gt;0.2%\/year) risk groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A novel HCC risk prediction model for non\u2010cirrhotic NAFLD patients was developed and validated with fair performance. The model is expected to serve as a simple and reliable tool to assess HCC risk and assist precision screening of HCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15819","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T03:54:24Z","timestamp":1702958064000},"page":"738-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A risk prediction model for hepatocellular carcinoma in\n                    <scp>non\u2010alcoholic<\/scp>\n                    fatty liver disease without cirrhosis"],"prefix":"10.1111","volume":"44","author":[{"given":"Gi\u2010Ae","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine College of Medicine Kyung Hee University Hospital Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yewan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine Kyung Hee University Hospital Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin Ju","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine Kyung Hee University Hospital Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jooyi","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Korea University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungbong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Korea University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye\u2010Sook","family":"Chang","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Won","family":"Park","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Hyup","family":"Kim","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Won","family":"Park","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center Asan Medical Center 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