{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:15:15Z","timestamp":1785795315654,"version":"3.56.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>During recent years, there have been major insight into the pathogenesis, diagnosis and treatment of autoimmune hepatitis (AIH). We aim to evaluate modifications of the clinical\u2010epidemiological phenotype of AIH patients from 1980 to our days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single\u2010centre, tertiary care retrospective study on 507 consecutive Italian patients with AIH. Patients were divided into four subgroups according to the decade of diagnosis: 1981\u20131990, 1991\u20132000, 2001\u20132010 and 2011\u20132020. We assessed clinical, laboratory and histological features at diagnosis, response to treatment and clinical outcomes. Acute presentation is defined as transaminase levels &gt;10\u2010fold the upper limit and\/or bilirubin &gt;5\u2009mg\/dL. Complete response is defined as the normalization of transaminases and IgG after 12\u2009months. Clinical progression is defined as the development of cirrhosis in non\u2010cirrhotic patients and hepatic decompensation\/hepatocellular carcinoma development in compensated cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median age at diagnosis increased across decades (24, 31, 39, 52\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Acute onset became more common (39.6%, 44.4%, 47.7%, 59.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.019), while cirrhosis at diagnosis became less frequent (36.5%, 16.3%, 10.8%, 8.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Complete response rates rose (11.1%, 49.4%, 72.7% 76.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and clinical progression during follow\u2010up decreased (54.3%, 29.9%, 16.9%, 11.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Anti\u2010nuclear antibodies positivity increased (40.7%, 52.0%, 73.7%, 79.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), while IgG levels\/upper limit progressively decreased (1.546, 1.515, 1.252, 1.120,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Liver\u2010related death and liver transplantation reduced from 17.1% to 2.1% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the new millennium, the typical AIH patient in Italy is older at diagnosis, more often presents with acute hepatitis, cirrhosis is less frequent and response to treatment is more favourable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15829","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T07:39:11Z","timestamp":1705477151000},"page":"791-798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The evolving phenotype of autoimmune hepatitis across the millennium: The 40\u2010year experience of a referral centre in Italy"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9547-6519","authenticated-orcid":false,"given":"Marco","family":"Ferronato","sequence":"first","affiliation":[{"name":"DIMEC, Universit\u00e0 di Bologna  Bologna Italy"},{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Lalanne","sequence":"additional","affiliation":[{"name":"DIMEC, Universit\u00e0 di Bologna  Bologna Italy"},{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Quarneti","sequence":"additional","affiliation":[{"name":"DIMEC, Universit\u00e0 di Bologna  Bologna Italy"},{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Panico","sequence":"additional","affiliation":[{"name":"DIMEC, Universit\u00e0 di Bologna  Bologna Italy"},{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Guidi","sequence":"additional","affiliation":[{"name":"DIMEC, Universit\u00e0 di Bologna  Bologna Italy"},{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Lenzi","sequence":"additional","affiliation":[{"name":"DIMEC, Universit\u00e0 di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8748-8031","authenticated-orcid":false,"given":"Luigi","family":"Muratori","sequence":"additional","affiliation":[{"name":"DIMEC, Universit\u00e0 di Bologna  Bologna Italy"},{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  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