{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:27:45Z","timestamp":1779395265416,"version":"3.53.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Alcohol\u2010related hepatitis (AH) is the most severe form of acute alcohol\u2010related liver disease. Maddrey's discriminant function \u226532 defines the severe form of AH, which is associated with a high mortality. Steroid therapy represents the main medical treatment that may reduce short\u2010term mortality. Lille score at day 7 assesses the therapeutic response to steroid therapy. At present, no parameters able to predict the response to steroid therapy have been highlighted. The aim of the present study was to evaluate if baseline prothrombin time (BPT) could predict the response to steroid in severe AH (sAH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients consecutively admitted in two Italian Liver Units, from 2017 to 2022, suffering from sAH were included. Data were collected prospectively. In order to evaluate if BPT could predict steroid response, we assessed the correlation between BPT using the Lille score at day 7.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 52 patients received steroid treatment were enrolled in the study. The response to therapy was assessed by Lille score at day 7. Responders were 34 patients (65%), non\u2010responders 18 patients (34%). BPT significantly predicted the steroid response (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). The likelihood of not responding to the steroid therapy was significantly higher in patients with higher BPT (OR\u2009=\u20092.954).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BPT value predicted steroid response in patients with sAH. BPT could quickly identify non\u2010responder patients to steroid therapy, reducing the risk of infections and it could allow the early evaluation for liver transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15835","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T23:54:55Z","timestamp":1705622095000},"page":"823-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prothrombin time predicts steroid response in severe alcohol\u2010related hepatitis"],"prefix":"10.1111","volume":"44","author":[{"given":"Claudia","family":"Tarli","sequence":"first","affiliation":[{"name":"Internal Medicine and Alcohol Related Disease Unit, Department of Medical and Surgical Sciences Columbus\u2010Gemelli Hospital, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Mannucci","sequence":"additional","affiliation":[{"name":"Internal Medicine and Alcohol Related Disease Unit, Department of Medical and Surgical Sciences Columbus\u2010Gemelli Hospital, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Vecchione","sequence":"additional","affiliation":[{"name":"Department of Social and Developmental Psychology Faculty of Medicine and Psychology Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Internal Medicine and Alcohol Related Disease Unit, Department of Medical and Surgical Sciences Columbus\u2010Gemelli Hospital, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Sestito","sequence":"additional","affiliation":[{"name":"Internal Medicine and Alcohol Related Disease Unit, Department of Medical and Surgical Sciences Columbus\u2010Gemelli Hospital, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Antonio","family":"Mancarella","sequence":"additional","affiliation":[{"name":"Internal Medicine and Alcohol Related Disease Unit, Department of Medical and Surgical Sciences Columbus\u2010Gemelli Hospital, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Tosoni","sequence":"additional","affiliation":[{"name":"Internal Medicine and Alcohol Related Disease Unit, Department of Medical and Surgical Sciences Columbus\u2010Gemelli Hospital, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Dionisi","sequence":"additional","affiliation":[{"name":"Internal Medicine and Alcohol Related Disease Unit, Department of Medical and Surgical Sciences Columbus\u2010Gemelli Hospital, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Maccauro","sequence":"additional","affiliation":[{"name":"Internal Medicine and Alcohol Related Disease Unit, Department of Medical and Surgical Sciences Columbus\u2010Gemelli Hospital, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Di","family":"Sario","sequence":"additional","affiliation":[{"name":"Internal Medicine and Alcohol Related Disease Unit, Department of Medical and Surgical Sciences Columbus\u2010Gemelli Hospital, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8791-191X","authenticated-orcid":false,"given":"Patrizia","family":"Burra","sequence":"additional","affiliation":[{"name":"Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology Padua University Hospital  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4332-2072","authenticated-orcid":false,"given":"Giacomo","family":"Germani","sequence":"additional","affiliation":[{"name":"Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology Padua University Hospital  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4863-6924","authenticated-orcid":false,"given":"Antonio","family":"Gasbarrini","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Department of Medical and Surgical Sciences Fondazione Policlinico Universitario A. 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