{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:40Z","timestamp":1787015740936,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is associated with increased risk for cardiovascular disease. Our study investigates the contribution of NAFLD to changes in cardiac structure and function in a general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One thousand ninety\u2010six adults (49.3% female) from the Study of Health in Pomerania underwent magnetic resonance imaging including cardiac and liver imaging. The presence of NAFLD by proton density fat fraction was related to left cardiac structure and function. Results were adjusted for clinical confounders using multivariable linear regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence for NAFLD was 35.9%. In adjusted multivariable linear regression models, NAFLD was positively associated with higher left ventricular mass index (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.95; 95% confidence interval (CI): 0.45; 1.45), left ventricular concentricity (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.043; 95% CI: 0.031; 0.056), left ventricular end\u2010diastolic wall thickness (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.29; 95% CI: 0.20; 0.38), left atrial end\u2010diastolic volume index (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.67; 95% CI: 0.01; 1.32) and inversely associated with left ventricular end\u2010diastolic volume index (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.78; 95% CI: \u22121.51; \u22120.05). When stratified by sex, we only found significant positive associations of NAFLD with left ventricular mass index, left atrial end\u2010diastolic volume index, left ventricular cardiac output and an inverse association with global longitudinal strain in women. In contrast, men had an inverse association with left ventricular end\u2010diastolic volume index and left ventricular stroke volume. Higher liver fat content was stronger associated with higher left ventricular mass index, left ventricular concentricity and left ventricular end\u2010diastolic wall thickness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NAFLD is associated with cardiac remodelling in the general population showing sex specific patterns in cardiac structure and function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15844","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T04:18:46Z","timestamp":1706674726000},"page":"1032-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cardiac remodelling in non\u2010alcoholic fatty liver disease in the general population"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5628-7082","authenticated-orcid":false,"given":"Frederik","family":"Kostka","sequence":"first","affiliation":[{"name":"Institute of Diagnostic Radiology and Neuroradiology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Ittermann","sequence":"additional","affiliation":[{"name":"Department of Study of Health in Pomerania\/Clinical\u2010Epidemiological Research, Institute for Community Medicine University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gro\u00df","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B University Medicine Greifswald  Greifswald Germany"},{"name":"German Centre for Cardiovascular Research (DZHK) Partner Site Greifswald  Greifswald 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