{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:55:38Z","timestamp":1793501738890,"version":"4.5.0"},"reference-count":79,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Type 2 diabetes mellitus (T2DM) and liver cirrhosis are clinical entities that frequently coexist, but glucose\u2010lowering medication options are limited in cirrhotic patients. Sodium\u2013glucose linked transporter 2 (SGLT2) inhibitors are a class of glucose\u2010lowering medication that act independently of insulin, by causing glycosuria in the proximal convoluted tubule. In this review, we aimed to briefly present the main data and to provide insight into the pathophysiology and potential usefulness of SGLT2 inhibitors in cirrhotic patients with or without T2DM. SGLT2 inhibitors have been proven useful as antidiabetic treatment in patients with metabolic liver disease, with most robust data from patients with metabolic dysfunction\u2010associated steatotic liver disease (MASLD), where they also showed improvement in liver function parameters. Moreover, it has been suggested that SGLT2 inhibitors may have effects beyond their antidiabetic action. Accordingly, they have exhibited cardioprotective effects, expanding their indication in patients with heart failure without T2DM. Since decompensated liver cirrhosis and congestive heart failure share common pathophysiological features, namely renin\u2013angiotensin\u2013aldosterone axis and sympathetic nervous system activation as well as vasopressin secretion, SGLT2 inhibitors could also be beneficial in patients with decompensated cirrhosis, even in the absence of T2DM.<\/jats:p>","DOI":"10.1111\/liv.15851","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T04:24:46Z","timestamp":1706675086000},"page":"884-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Sodium\u2013glucose linked transporter 2 inhibitors in liver cirrhosis: Beyond their antidiabetic use"],"prefix":"10.1111","volume":"44","author":[{"given":"Christos","family":"Siafarikas","sequence":"first","affiliation":[{"name":"1st Propaedeutic Department of Internal Medicine Medical School of National and Kapodistrian University of Athens, General Hospital of Athens \u201cLaiko\u201d  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris J.","family":"Kapelios","sequence":"additional","affiliation":[{"name":"Heart Failure and Heart Transplantation Unit Onassis Cardiac Surgery Center  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8581-6591","authenticated-orcid":false,"given":"Margarita","family":"Papatheodoridi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Medical School of National and Kapodistrian University of Athens, General Hospital of Athens \u201cLaiko\u201d  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3680-8194","authenticated-orcid":false,"given":"John","family":"Vlachogiannakos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Medical School of National and Kapodistrian University of Athens, General Hospital of Athens \u201cLaiko\u201d  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Tentolouris","sequence":"additional","affiliation":[{"name":"1st Propaedeutic Department of Internal Medicine Medical School of National and Kapodistrian University of Athens, General Hospital of Athens \u201cLaiko\u201d  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3518-4060","authenticated-orcid":false,"given":"George","family":"Papatheodoridis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Medical School of National and Kapodistrian University of Athens, General Hospital of Athens \u201cLaiko\u201d  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05787-2"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.280"},{"key":"e_1_2_14_5_1","article-title":"Diabetes mellitus and risk of hepatic fibrosis\/cirrhosis","volume":"2019","author":"Li X","year":"2019","journal-title":"Biomed Res Int"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01374-X"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i1.61"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.024"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.12.022"},{"issue":"5","key":"e_1_2_14_10_1","article-title":"The role of incretin hormones and glucagon in patients with liver disease","volume":"64","author":"Junker AE","year":"2017","journal-title":"Dan Med J"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27228"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.04.002"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12670"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.243"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051013-110046"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-015-0264-4"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170530075533"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1811744"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911303"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2022190"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107038"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206286"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2333"},{"issue":"18","key":"e_1_2_14_25_1","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA Guideline for the Management of Heart Failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich PA","year":"2022","journal-title":"Circulation"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01659-1"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.1891"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13126"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4670-7"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2018.07.006"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2214"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-020-09995-z"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i16.1974"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.03.009"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)91026-E"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90025-8"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-031620-095920"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.09.013"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.714"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.011"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2001.281.4.F718"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00357.2011"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-016-0457-8"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2724"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-017-0125-x"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72227"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-2604"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0654-z"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(20)31702-2"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.045691"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2066"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048739"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-020-01597-x"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.047077"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230122"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007362"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220308"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31270"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.13136"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000995"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfab266"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14488"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3432-8"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102813"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.210"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02468.x"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep097"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-0012"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2021.107913"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-02250-9"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12183"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.09.011"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-019-0912-3"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037076"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004007"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-2207"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01574-w"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2687"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12401"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2020.07.013"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T09:53:42Z","timestamp":1711101222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.15851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,31]]},"references-count":79,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/liv.15851"],"URL":"https:\/\/doi.org\/10.1111\/liv.15851","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,31]]},"assertion":[{"value":"2023-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}