{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:53:13Z","timestamp":1774288393411,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The effectiveness of percutaneous radiofrequency ablation (RFA) in intrahepatic cholangiocarcinomas (iCCA) remains insufficiently studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study including patients with histologically proven iCCA within Milan criteria treated by percutaneous RFA from 2000 to 2022. The primary outcome was overall survival in treatment\u2010naive patients and secondary outcomes included ablation completeness, adverse events, local and distant recurrence. A total of 494 patients with hepatocellular carcinoma (HCC) on cirrhosis treated by RFA were included as a comparison group. Oncological events were analysed using Kaplan\u2013Meier, log\u2010rank and univariate\/multivariate Cox models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The main population included 71 patients, mostly cirrhotic (80%) with solitary tumours (66%) of a median size of 24\u2009mm. Local recurrence was 45% at 5\u2009years, lower in multibipolar versus monopolar RFA (22% vs. 55%, <jats:italic>p<\/jats:italic>\u2009=\u2009.007). In treatment\u2010naive patients (<jats:italic>n<\/jats:italic>\u2009=\u200945), median overall and recurrence\u2010free survivals were 26 and 11\u2009months, respectively. Tumour size (<jats:italic>p<\/jats:italic>\u2009=\u2009.01) and Child\u2010Pugh B (<jats:italic>p<\/jats:italic>\u2009=\u2009.001) were associated with death. The rate of distant recurrence was 59% at 5\u2009years significantly lower for single tumours of less than 2 (<jats:italic>p<\/jats:italic>\u2009=\u2009.002) or 3\u2009cm (<jats:italic>p<\/jats:italic>\u2009=\u2009.02). In cirrhotic patients na\u00efve of previous treatment (<jats:italic>n<\/jats:italic>\u2009=\u200940), overall survival was shorter than in HCC (26 vs 68\u2009months, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001), with more local recurrences (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). Among distant recurrences, 50% were extrahepatic metastases compared to 12% in HCC (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Multibipolar RFA provides better results in terms of tumour recurrence than monopolar RFA and could be used to treat small iCCA (&lt;3\u2009cm). Adjuvant chemotherapy should be discussed due to the frequent extra\u2010hepatic metastasis at recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15886","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T12:49:08Z","timestamp":1709556548000},"page":"1363-1372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term oncological results of percutaneous radiofrequency ablation for intrahepatic cholangiocarcinoma"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8499-4069","authenticated-orcid":false,"given":"Cl\u00e9mentine","family":"Alitti","sequence":"first","affiliation":[{"name":"Liver Unit, Avicenne Hospital, APHP Paris Nord University  Bobigny France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Rode","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital Croix\u2010Rousse Hospices Civils de Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Trillaud","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Bordeaux  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Merle","sequence":"additional","affiliation":[{"name":"Cancer Research Center of Lyon (CRCL), INSERM U1052, Centre National de la Recherche Scientifique UMR5286  Lyon France"},{"name":"Department of Hepatology, H\u00f4pital Croix\u2010Rousse Hospices Civils de Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Fr\u00e9d\u00e9ric","family":"Blanc","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology CHU Bordeaux  Bordeaux 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Sorbonne Universit\u00e9, Inserm, Universit\u00e9 de Paris, Team \u00abFunctional Genomics of Solid Tumors\u00bb, Equipe labellis\u00e9e Ligue Nationale Contre le Cancer, Labex OncoImmunology  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Ganne\u2010Carri\u00e9","sequence":"additional","affiliation":[{"name":"Liver Unit, Avicenne Hospital, APHP Paris Nord University  Bobigny France"},{"name":"Cordeliers Research Center, Sorbonne Universit\u00e9, Inserm, Universit\u00e9 de Paris, Team \u00abFunctional Genomics of Solid Tumors\u00bb, Equipe labellis\u00e9e Ligue Nationale Contre le Cancer, Labex OncoImmunology  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Petit","sequence":"additional","affiliation":[{"name":"Interventional Radiology Unit Avicenne Hospital, APHP  Bobigny 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