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Earlier identification of ARLD may lead to reduced alcohol intake, participation in hepatocellular carcinoma surveillance and reduction in liver\u2010related morbidity and mortality. People with alcohol use disorder (AUD) are at highest risk of ARLD. The aim of this systematic review was to understand the yield of proactive screening for ARLD amongst high\u2010risk groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Embase, Medline, Scopus and grey literature were searched for studies describing proactive assessment for alcohol\u2010related liver disease in people with a history of alcohol excess or diagnosed AUD. Outcomes of interest were fibrosis and cirrhosis detection rates, clinical outcomes, portal hypertension evaluation, attendance at follow\u2010up and cost\u2010effectiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen studies were identified for inclusion from 1115 returned by the search. Four key settings for patient engagement were identified as inpatient addiction services, outpatient addiction services, general acute hospital admissions and community outreach. Of these, acute hospital admissions were the highest yield for cirrhosis at 10.8%\u201329.6% and community outreach the lowest was 1.2%\u20132.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Targeted fibrosis assessment of high\u2010risk populations for ARLD is feasible to conduct and identifies a proportion of patients at risk of advanced liver disease. The highest yield is amongst inpatients admitted with AUD. Prospective work is needed to establish which are the most effective and acceptable screening methods and the impact on long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15895","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T13:39:17Z","timestamp":1709905157000},"page":"1298-1308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Proactive case finding of alcohol\u2010related liver disease in high\u2010risk populations: A systematic review"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4185-4454","authenticated-orcid":false,"given":"Ann J.","family":"Archer","sequence":"first","affiliation":[{"name":"Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"},{"name":"Department of Liver Medicine, Bristol Royal Infirmary University Hospitals Bristol and Weston Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6724-6940","authenticated-orcid":false,"given":"Jennifer","family":"Phillips","sequence":"additional","affiliation":[{"name":"Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"},{"name":"Department of Liver Medicine, Bristol Royal Infirmary University Hospitals Bristol and Weston Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8739-7263","authenticated-orcid":false,"given":"Mohsan","family":"Subhani","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Biomedical Research Centre (NDDC), School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0268-988X","authenticated-orcid":false,"given":"Zoe","family":"Ward","sequence":"additional","affiliation":[{"name":"Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6026-4351","authenticated-orcid":false,"given":"Fiona H.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Liver Medicine, Bristol Royal Infirmary University Hospitals Bristol and Weston Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-459X","authenticated-orcid":false,"given":"Matthew","family":"Hickman","sequence":"additional","affiliation":[{"name":"Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-0193","authenticated-orcid":false,"given":"Ashwin D.","family":"Dhanda","sequence":"additional","affiliation":[{"name":"Hepatology Research Group, Faculty of Health University of Plymouth  Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7301-8250","authenticated-orcid":false,"given":"Kushala W. 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