{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:58:06Z","timestamp":1792706286215,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognosis of metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is associated with liver fibrosis. We investigated the associations between changes in liver stiffness measurement (LSM) over 3\u2010year period and the development of cirrhosis or hepatocellular carcinoma (HCC) in patients with MASLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study involved patients with MASLD who underwent transient elastography at baseline and 3\u2009years after baseline from 2012 to 2020. Low (L), indeterminate (I) and high (H) LSM values were classified as &lt;8\u2009kPa, 8\u201312\u2009kPa and &gt;12\u2009kPa respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1738 patients, 150 (8.6%) were diagnosed with cirrhosis or HCC. The proportions of patients with L, I and H risk were 69.7%, 19.9% and 10.5% at baseline, and 78.8%, 12.8% and 8.4% at 3\u2009years after baseline, respectively. The incidence rates of cirrhosis or HCC per 1000 person\u2010years were 3.7 (95% confidence interval [CI], 2.4\u20135.5) in the L\u2009\u2192\u2009L\u2009+\u2009I group, 23.9 (95% CI, 17.1\u201332.6) in the I\u2009\u2192\u2009L\u2009+\u2009I group, 38.3 (95% CI, 22.3\u201361.3) in the H\u2009\u2192\u2009L\u2009+\u2009I group, 62.5 (95% CI, 32.3\u2013109.2) in the I\u2009\u2192\u2009H group, 67.8 (95% CI, 18.5\u2013173.6) in the L\u2009\u2192\u2009H group and 93.9 (95% CI 70.1\u2013123.1) in the H\u2009\u2192\u2009H group. Two risk factors for the development of cirrhosis or HCC were LSM changes and low platelet counts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LSM changes could predict clinical outcomes in patients with MASLD. Thus, it is important to monitor changes in the fibrotic burden by regular assessment of LSM values.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15897","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T06:26:45Z","timestamp":1710570405000},"page":"1448-1455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The associations between fibrosis changes and liver\u2010related events in patients with metabolic dysfunction\u2010associated steatotic liver disease"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3552-3560","authenticated-orcid":false,"given":"Hye Won","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Yonsei Liver Center, Severance Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-4624","authenticated-orcid":false,"given":"Sang Hoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Yonsei Liver Center, Severance Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Chu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Liver Center, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7470-5850","authenticated-orcid":false,"given":"Jonggi","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Liver Center, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of 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