{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:10Z","timestamp":1787015710746,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T00:00:00Z","timestamp":1712361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We aim to assess the long\u2010term outcomes of percutaneous multi\u2010bipolar radiofrequency (mbpRFA) as the first treatment for hepatocellular carcinoma (HCC) in transplant\u2010eligible cirrhotic patients, followed by salvage transplantation for intrahepatic distant tumour recurrence or liver failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We included transplant\u2010eligible patients with cirrhosis and a first diagnosis of HCC within Milan criteria treated by upfront mbp RFA. Transplantability was defined by age &lt;70\u2009years, social support, absence of significant comorbidities, no active alcohol use and no recent extrahepatic cancer. Baseline variables were correlated with outcomes using the Kaplan\u2010Meier and Cox models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 435 patients with HCC, 172 were considered as transplantable with HCCs &gt;2\u2009cm (53%), uninodular (87%) and AFP &gt;100\u2009ng\/mL (13%). Median overall survival was 87\u2009months, with 75% of patients alive at 3\u2009years, 61% at 5\u2009years and 43% at 10\u2009years. Age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003) and MELD&gt;10 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01) were associated with the risk of death. Recurrence occurred in 118 patients within Milan criteria in 81% of cases. Local recurrence was observed in 24.5% of cases at 10\u2009years and distant recurrence rates were observed in 69% at 10\u2009years. After local recurrence, 69% of patients were still alive at 10\u2009years. At the first tumour recurrence, 75 patients (65%) were considered transplantable. Forty\u2010one patients underwent transplantation, mainly for distant intrahepatic tumour recurrence. The overall 5\u2010year survival post\u2010transplantation was 72%, with a tumour recurrence of 2.4%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Upfront multi\u2010bipolar RFA for a first diagnosis of early HCC on cirrhosis coupled with salvage liver transplantation had a favourable intention\u2010to\u2010treat long\u2010term prognosis, allowing for spare grafts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15900","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T04:44:56Z","timestamp":1712378696000},"page":"1464-1473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Upfront multi\u2010bipolar radiofrequency ablation for\n                    <scp>HCC<\/scp>\n                    in transplant\u2010eligible cirrhotic patients with salvage transplantation in case of recurrence"],"prefix":"10.1111","volume":"44","author":[{"given":"Carina","family":"Boros","sequence":"first","affiliation":[{"name":"Liver Unit, Avicenne Hospital, APHP Paris Nord University  Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Sutter","sequence":"additional","affiliation":[{"name":"Interventional Radiology Unit, Avicenne Hospital, APHP Paris Nord University  Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Cauchy","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Ganne\u2010Carri\u00e9","sequence":"additional","affiliation":[{"name":"Liver Unit, Avicenne Hospital, APHP Paris Nord University  Bobigny 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