{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:12:20Z","timestamp":1790460740790,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>This study aimed to determine the safety and efficacy of atezolizumab + bevacizumab therapy in hepatocellular carcinoma patients receiving anti\u2010platelet agents or anticoagulants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were divided into those using (IM out) and those not using (IM in) anti\u2010platelet agents or anticoagulants, who violated the exclusion criteria of the IMbrave150 trial, and were retrospectively examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 185 patients (IM in: 157; IM out: 28). For first\u2010line treatment, progression\u2010free survival was 184\u2009days for IM in and 266\u2009days for IM out (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.136). Overall survival was 603\u2009days for IM in and not reached for IM out (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.265), with no significant between\u2010group difference. Similarly, there were no significant between\u2010group differences in progression\u2010free survival or overall survival for later\u2010line treatment. Haemorrhagic adverse events of \u2265grade 3 were observed in 11 IM in patients and 3 IM out patients. No significant factors associated with haemorrhagic adverse events of \u2265grade 3 were identified in the multivariate analysis including IM out classification, whose\n                      <jats:italic>p<\/jats:italic>\n                      value was .547. Regarding thrombotic\/embolic adverse events in the IM out group, one case of exacerbation of portal vein thrombosis was observed. No deaths were directly attributable to bleeding events or exacerbations of thrombosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Atezolizumab + bevacizumab therapy shows similar safety and efficacy in patients receiving and those not receiving anti\u2010platelet agents or anticoagulants; therefore, it can be considered for patients with hepatocellular carcinoma receiving anti\u2010platelet agents or anticoagulants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15918","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T02:53:55Z","timestamp":1717556035000},"page":"1751-1761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Safety\/efficacy of atezolizumab + bevacizumab during anti\u2010platelet\/anticoagulation therapy in unresectable hepatocellular carcinoma"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9779-4369","authenticated-orcid":false,"given":"Michihisa","family":"Moriguchi","sequence":"first","affiliation":[{"name":"Molecular Gastroenterology and Hepatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichiro","family":"Okuda","sequence":"additional","affiliation":[{"name":"Molecular Gastroenterology and Hepatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"},{"name":"Department of Gastroenterology and Hepatology Saiseikai Suita Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Horiguchi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seita","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Molecular Gastroenterology and Hepatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3658-5894","authenticated-orcid":false,"given":"Yuya","family":"Seko","sequence":"additional","affiliation":[{"name":"Molecular Gastroenterology and Hepatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0631-046X","authenticated-orcid":false,"given":"Kanji","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Molecular Gastroenterology and Hepatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Kyoto Daiichi Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Kyoto Daiichi Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhide","family":"Mitsumoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Saiseikai Suita Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kyoto City Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Kirishima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kyoto City Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Okishio","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fukuchiyama City Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasuku","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fukuchiyama City Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Omihachiman Community Medical Center  Omihachiman Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Nagao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Matsushita Memorial Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayasu","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Otsu City Hospital  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ayabe City Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiyu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Center for Digestive and Liver Diseases Nara City Hospital  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihito","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Akashi City Hospital  Akashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Mitsuyoshi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kyoto Chubu Medical Center  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Kyoto Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Taketani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Koseikai Takeda Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology North Medical Center of Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kyoto Yamashiro General Medical Center  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Umemura","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Kyoto Prefectural University of Medicine Graduate School of Medical Science  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Itoh","sequence":"additional","affiliation":[{"name":"Molecular Gastroenterology and Hepatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708857"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32453-9"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30207-1"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1717002"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30937-9"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915745"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2100070"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15020348"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1381"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30156-X"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01868-2"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080455"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14977"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.08.024"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32511-3"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATV.0000000000000153"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-320622"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000799"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_13_21_1","unstructured":"National Cancer Institute.Protocol development cancer therapy.https:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/ctc.htm\u2010ctc_40"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-019-00757-w"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15153893"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-011-0642-1"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.08.024"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-022-00357-2"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02605"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528979"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15918","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.15918","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:06:36Z","timestamp":1772996796000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.15918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/liv.15918"],"URL":"https:\/\/doi.org\/10.1111\/liv.15918","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,4]]},"assertion":[{"value":"2023-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}