{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:30:46Z","timestamp":1790775046687,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Liver stiffness measurement (LSM) by vibration\u2010controlled transient elastography (VCTE) is a non\u2010invasive diagnostic biomarker of liver fibrosis. It is uncertain if LSM can predict risk for future liver\u2010related outcomes in large, heterogenous populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This Swedish multi\u2010centre cohort study included patients (<jats:italic>n<\/jats:italic>\u2009=\u200914\u2009414) from 16 sites who underwent LSM by VCTE between 2008 and 2020. Outcomes were ascertained from national registers. We investigated progression to cirrhosis with portal hypertension or hepatocellular carcinoma (HCC), separately. Cox regression was used to obtain hazard ratios (HRs). Harrel's C\u2010index was used to measure discrimination of VCTE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Included patients had a median age of 46 (interquartile range 34\u201357), median LSM of 5.9\u2009kPa (4.6\u20138.0), 59% were male, and the majority had hepatitis C (50.1%). During a median follow\u2010up of 5.9 (4.3\u20138.0) years, 402 patients (2.7%) developed cirrhosis with portal hypertension. In patients with an LSM \u226525\u2009kPa, 28.7% developed cirrhosis with portal hypertension within 5\u2009years of follow\u2010up, while only .6% of patients with an LSM &lt;10\u2009kPa did. This translated to a HR of 48.3 (95% confidence interval\u2009=\u200937.6\u201362.0). VCTE had a high discriminative ability, with C\u2010indices above .80 for most liver diseases, including .82 for MASLD. Similar findings were seen for incident HCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased LSM by VCTE was associated with an increased risk of progression to both cirrhosis with portal hypertension, and to HCC, and had a high discriminative ability across different aetiologies of chronic liver diseases. These results support the use of VCTE to guide follow\u2010up and treatment decisions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15919","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T13:01:09Z","timestamp":1711976469000},"page":"1689-1699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Liver stiffness predicts progression to liver\u2010related events in patients with chronic liver disease \u2013 A cohort study of 14\u2009414 patients"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6965-7738","authenticated-orcid":false,"given":"Hannes","family":"Hegmar","sequence":"first","affiliation":[{"name":"Division of Hepatology, Department of Upper GI Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Medicine Huddinge, Karolinska Institutet  Stockholm 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