{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:14:14Z","timestamp":1791947654003,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>The predictors of progression from steatosis to more advanced stages of metabolic dysfunction\u2013associated steatotic liver disease (MASLD) remain unclear. We evaluated the association between the quantity of hepatic steatosis and longitudinal changes in liver stiffness measurements (LSMs) using magnetic resonance elastography (MRE) in patients with MASLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed patients with MASLD who underwent at least two serial MRE and magnetic resonance imaging\u2013based proton density fat fraction (MRI\u2010PDFF) examinations at least 1\u2009year apart. Fine\u2010Gray competitive proportional hazard regression was used to identify LSM progression and regression factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 471 patients were enrolled. Factors linked to LSM progression were steatosis grade 3 (MRI\u2010PDFF \u226517.1%, adjusted hazard ratio [aHR] 2.597; 95% confidence interval [CI] 1.483\u20134.547) and albumin\u2013bilirubin grade 2 or 3 (aHR 2.790; 95% CI 1.284\u20136.091), while the only factor linked to LSM regression was % decrease rate of MRI\u2010PDFF \u22655% (aHR 2.781; 95% CI 1.584\u20134.883). Steatosis grade 3 correlated with a higher incidence rate of LSM progression than steatosis grade 1 (MRI\u2010PDFF &lt;11.3%) in patients with LSM stage 0 (&lt;2.5 kilopascal [kPa]), and a % annual decrease rate of MRI\u2010PDFF \u22655% correlated with a higher incidence rate of LSM regression than that of MRI\u2010PDFF &gt;\u22125% and &lt;5% in patients with LSM stage 1 or 2\u20134 (\u22652.5\u2009kPa).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severe hepatic steatosis was linked to significant LSM progression in patients with MASLD and low LSM (&lt;2.5\u2009kPa).<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15920","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T12:48:31Z","timestamp":1711975711000},"page":"1700-1714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Severe hepatic steatosis promotes increased liver stiffness in the early stages of metabolic dysfunction\u2013associated steatotic liver disease"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-495X","authenticated-orcid":false,"given":"Takashi","family":"Kumada","sequence":"first","affiliation":[{"name":"Department of Nursing, Faculty of Nursing Gifu Kyoritsu University  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-6168","authenticated-orcid":false,"given":"Hidenori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital  Ogaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2916-5875","authenticated-orcid":false,"given":"Sadanobu","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Imaging Diagnosis Ogaki Municipal Hospital  Ogaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8097-0757","authenticated-orcid":false,"given":"Tatsuya","family":"Gotoh","sequence":"additional","affiliation":[{"name":"Department of Imaging Diagnosis Ogaki Municipal Hospital  Ogaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7081-5625","authenticated-orcid":false,"given":"Yasuaki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nayoro City General Hospital  Nayoro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-7806","authenticated-orcid":false,"given":"Katsutoshi","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7025-7675","authenticated-orcid":false,"given":"Yuichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Suita Municipal Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1471-1087","authenticated-orcid":false,"given":"Hidekatsu","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Department of Internal Medicine Iwate Medical University  Iwate Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-902X","authenticated-orcid":false,"given":"Yoshihiro","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Advanced Metabolic Hepatology Osaka University Graduate School of Medicine  Osaka 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