{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:36:33Z","timestamp":1788456993119,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aims<\/jats:title>\n \n Holmium\u2010166 (\n 166<\/jats:sup>\n Ho) radioembolization could offer a more individualized approach in terms of imaging and dosimetry. We aim to evaluate the feasibility and safety of\n 166<\/jats:sup>\n Ho selective internal radiation therapy (SIRT) using a higher tumour dose than previously administered determined by\n 166<\/jats:sup>\n Ho\u2010scout as a surrogate marker in HCC patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This is an open\u2010label, prospective, non\u2010randomized, single\u2010centre pilot study that included patients with HCC that received\n 166<\/jats:sup>\n Ho\u2010SIRT if the work\u2010up using\n 166<\/jats:sup>\n Ho\u2010scout showed a tumour\u2010absorbed dose \u2265150\u2009Gy, a non\u2010tumoural liver absorbed dose less than 60\u2009Gy and a lung absorbed dose less than 30\u2009Gy. Primary endpoints were feasibility and safety\u2013toxicity profiles at 24\u201348\u2009h and 1\u2009month. Overall response rates (ORR) at 3\u2009months (mRECIST, RECIST 1.1 and metabolic response by FDG and choline PET CT) and time to progression (TTP) represented the secondary endpoints.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Fifteen patients with large tumours (mean diameter 55.67\u2009\u00b1\u200928.42\u2009mm) received 17\n 166<\/jats:sup>\n Ho\u2010SIRT treatments between July 2020 and June 2022. All the attempted treatments were accomplished. Mean administered tumour dose was 183.18\u2009\u00b1\u200971.71\u2009Gy, while non\u2010tumour liver dose was 30.29\u2009\u00b1\u200914.56\u2009Gy. Median time of follow\u2010up was 12\u2009months (IQR 9\u201316). Only grade 1\u20132 clinical and biological AEs were observed. There were no liver decompensations. At 3\u2009months, objective response was achieved for all target lesions (CR 78.57%, PR 21.43% according to mRECIST). Median TTP was 18.8 (range 2.9; n.e.) months.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Personalized\n 166<\/jats:sup>\n Ho\u2010SIRT with a tumour delivered dose \u2265150\u2009Gy was feasible and safe for HCC patients with promising response rates.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.15923","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T07:25:32Z","timestamp":1732173932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\n 166<\/sup>\n Ho\u2010RadioEmbolizaTiOn\n <\/scp>\n Using personalized\n prediCtive<\/scp>\n dosimetry in patients with Hepatocellular carcinoma: A prospective, single\u2010centre study (\n RETOUCH<\/scp>\n 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