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Proteomic screening tests were performed to identify the key factors mediating GCN5L1 loss\u2010induced ALD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Gene Expression Omnibus data set analysis indicates that GCN5L1 expression is negatively associated with ALD progression. GCN5L1 hepatic knockout mice develop severe liver injury and lipid accumulation when fed an alcohol diet. Screening tests identified that GCN5L1 targeted the mitochondrial iron transporter CISD1 to regulate mitochondrial iron homeostasis in ethanol\u2010induced ferroptosis. GCN5L1\u2010modulated CISD1 acetylation and activity were crucial for iron accumulation and ferroptosis in response to alcohol exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pharmaceutical modulation of CISD1 activity is critical for cellular iron homeostasis and ethanol\u2010induced ferroptosis. The GCN5L1\/CISD1 axis is crucial for oxidative stress and ethanol\u2010induced ferroptosis in ALD and is a promising avenue for novel therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15936","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T07:39:30Z","timestamp":1712734770000},"page":"1924-1936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Loss of\n                    <scp>GCN5L1<\/scp>\n                    exacerbates damage in alcoholic liver disease through ferroptosis activation"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9469-4460","authenticated-orcid":false,"given":"Chenxi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pharmacology, State Key Laboratory of Experimental Hematology, Tianjin Key Laboratory of Inflammatory Biology, The Province and Ministry Co\u2010Sponsored Collaborative Innovation Centre for Medical Epigenetics, NHC Key Laboratory of Hormones and Development Chu Hsien\u2010I Memorial Hospital and Tianjin Institute of Endocrinology, School of Basic Medical Sciences, Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, State Key Laboratory of Experimental Hematology, Tianjin Key Laboratory of Inflammatory Biology, The Province and Ministry Co\u2010Sponsored Collaborative Innovation Centre for Medical Epigenetics, NHC Key Laboratory of Hormones and Development Chu Hsien\u2010I Memorial Hospital and Tianjin Institute of Endocrinology, School of Basic Medical Sciences, Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuya","family":"Hu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Cell 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