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Decreasing muscle fat could be indirectly hepatoprotective in MASLD. We conducted a review to identify interventions reducing myosteatosis and their impact on liver function. Non\u2010pharmacological interventions included diet (caloric restriction or lipid enrichment), bariatric surgery and physical activity. Caloric restriction in humans achieving a mean weight loss of 3% only reduces muscle fat. Lipid\u2010enriched diet increases liver fat in human with no impact on muscle fat, except sphingomyelin\u2010enriched diet which reduces both lipid contents exclusively in pre\u2010clinical studies. Bariatric surgery, hybrid training (resistance exercise and electric stimulation) or whole\u2010body vibration in human decrease both liver and muscle fat. Physical activity impacts both phenotypes by reducing local and systemic inflammation, enhancing insulin sensitivity and modulating the expression of key mediators of the muscle\u2010liver\u2010adipose tissue axis. The combination of diet and physical activity acts synergistically in liver, muscle and white adipose tissue, and further decrease muscle and liver fat. Several pharmacological interventions (patchouli alcohol, KBP\u2010089, 2,4\u2010dinitrophenol methyl ether, adipoRon and atglistatin) and food supplementation (vitamin D or resveratrol) improve liver and muscle phenotypes in pre\u2010clinical studies by increasing fatty acid oxidation and anti\u2010inflammatory properties. These interventions are effective in reducing myosteatosis in MASLD while addressing the liver disease itself. This review supports that disturbances in inter\u2010organ crosstalk are key pathophysiological mechanisms involved in MASLD and myosteatosis pathogenesis. Focusing on the skeletal muscle might offer new therapeutic strategies to treat MASLD by modulating the interactions between liver and muscles.<\/jats:p>","DOI":"10.1111\/liv.15938","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T04:33:16Z","timestamp":1713241996000},"page":"1781-1796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Unlocking liver health: Can tackling myosteatosis spark remission in metabolic dysfunction\u2010associated steatotic liver disease?"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3020-3664","authenticated-orcid":false,"given":"Guillaume","family":"Henin","sequence":"first","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastroent\u00e9rologie Cliniques universitaires Saint\u2010Luc, UCLouvain  Brussels Belgium"},{"name":"Laboratory of Hepatogastroenterology, Institut de Recherche Exp\u00e9rimentale et 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