{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:28:35Z","timestamp":1788366515692,"version":"build-2803163510"},"reference-count":207,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Intrahepatic cholangiocarcinoma (iCCA) is the second most common malignant primary liver cancer. iCCA may develop on an underlying chronic liver disease and its incidence is growing in relation with the epidemics of obesity and metabolic diseases. In contrast, perihilar cholangiocarcinoma (pCCA) may follow a history of chronic inflammatory diseases of the biliary tract. The initial management of CCAs is often complex and requires multidisciplinary expertise. The French Association for the Study of the Liver wished to organize guidelines in order to summarize the best evidence available about several key points in iCCA and pCCA. These guidelines have been elaborated based on the level of evidence available in the literature and each recommendation has been analysed, discussed and voted by the panel of experts. They describe the epidemiology of CCA as well as how patients with iCCA or pCCA should be managed from diagnosis to treatment. The most recent developments of personalized medicine and use of targeted therapies are also highlighted.<\/jats:p>","DOI":"10.1111\/liv.15948","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T11:30:59Z","timestamp":1720179059000},"page":"2517-2537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Management of intrahepatic and perihilar cholangiocarcinomas: Guidelines of the French Association for the Study of the Liver (\n                    <scp>AFEF<\/scp>\n                    )"],"prefix":"10.1111","volume":"44","author":[{"given":"Cindy","family":"Neuzillet","sequence":"first","affiliation":[{"name":"GI Oncology, Medical Oncology Department, Institut Curie Versailles Saint\u2010Quentin University, Paris Saclay University  Saint\u2010Cloud France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Decraecker","sequence":"additional","affiliation":[{"name":"Oncology Digestive Unit, INSERM U1312 University Hospital of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Larrue","sequence":"additional","affiliation":[{"name":"Department of Hepatology University Hospital, Toulouse III\u2010Paul Sabatier University  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line C.","family":"Ntanda\u2010Nwandji","sequence":"additional","affiliation":[{"name":"INSERM U1286 INFINITE, University Hospital of Lille France  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Barbier","sequence":"additional","affiliation":[{"name":"New Zealand Liver Transplant Unit and HPB Surgery, Te Toka Tumai University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Barge","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Intercommunal Cr\u00e9teil\u2014CHI Cr\u00e9teil  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Belle","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Digestive Oncology Cochin Hospital, Assistance Publique\u2014H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Chagneau","sequence":"additional","affiliation":[{"name":"Polyclinique Bordeaux Rive Droite  Lormont France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Edeline","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology CLCC Eug\u00e8ne Marquis, COSS\u2010UMR S1242, INSERM, Univ Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Guettier","sequence":"additional","affiliation":[{"name":"Department of Pathology APHP University Paris Saclay, H\u00f4pital Bicetre  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Huguet","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department Tenon Hospital, APHP\u2010Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Jacques","sequence":"additional","affiliation":[{"name":"H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie CHU de Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Le\u00a0Bail","sequence":"additional","affiliation":[{"name":"Pathology Department University Hospital of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Leblanc","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Private Hospital Jean Mermoz, Ramsay Sant\u00e9  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00eft\u00e9","family":"Lewin","sequence":"additional","affiliation":[{"name":"Service de Radiologie AP\u2010HP\u2010Universit\u00e9 Paris Saclay H\u00f4pital Paul Brousse  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Malka","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Institut Mutualiste Monsouris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Ronot","sequence":"additional","affiliation":[{"name":"Department of Radiology Beaujon Hospital, APHP Nord Clichy, University Paris Cit\u00e9, CRI UMR  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Vendrely","sequence":"additional","affiliation":[{"name":"Radiotherapy Department Bordeaux University Hospital  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Vibert","sequence":"additional","affiliation":[{"name":"Centre Hepato\u2010Biliaire AP\u2010HP\u2010Universit\u00e9 Paris Saclay H\u00f4pital Paul Brousse  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7669-7698","authenticated-orcid":false,"given":"Christophe","family":"Bureau","sequence":"additional","affiliation":[{"name":"Department of Hepatology University Hospital, Toulouse III\u2010Paul Sabatier University  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bourliere","sequence":"additional","affiliation":[{"name":"Liver Unit Saint Joseph Hopital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Ganne\u2010Carrie","sequence":"additional","affiliation":[{"name":"Hepatology Department AP\u2010HP, Avicenne Hospital  Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fr\u00e9d\u00e9ric","family":"Blanc","sequence":"additional","affiliation":[{"name":"Oncology Digestive Unit, INSERM U1312 University Hospital of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.09.008"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199610000-00005"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.09.007"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186643"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.12.048"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01796.x"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.05.020"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.022"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069981"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(05)80014-9"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2005.10.003"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004355"},{"issue":"44","key":"e_1_2_18_14_1","first-page":"326","article-title":"Macroscopic types of intrahepatic cholangiocarcinoma: clinicopathologic features and surgical outcomes","volume":"49","author":"Hirohashi K","year":"2002","journal-title":"Hepato\u2010Gastroenterology"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.04.012"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.1410"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.12.010"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(83)90164-2"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-014-2831-5"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i2.249"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200008000-00011"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2008.02264.x"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.3350\/kjhep.2011.17.2.161"},{"issue":"6","key":"e_1_2_18_24_1","first-page":"3112","article-title":"Clinicopathological characterization of so\u2010called \u201ccholangiocarcinoma with intraductal papillary growth\u201d with respect to \u201cintraductal papillary neoplasm of bile duct (IPNB)\u201d","volume":"7","author":"Nakanuma Y","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.776"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(94)90009-4"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21146"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2021.101775"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14662"},{"key":"e_1_2_18_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs351"},{"key":"e_1_2_18_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.743"},{"key":"e_1_2_18_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23508"},{"key":"e_1_2_18_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990412)81:2<214::AID-IJC8>3.0.CO;2-L"},{"key":"e_1_2_18_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2008.01125.x"},{"key":"e_1_2_18_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.11.030"},{"key":"e_1_2_18_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0127"},{"key":"e_1_2_18_37_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018171187"},{"key":"e_1_2_18_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/13651820801992617"},{"key":"e_1_2_18_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-020-02559-7"},{"key":"e_1_2_18_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2017-000472"},{"key":"e_1_2_18_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05173.x"},{"key":"e_1_2_18_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13139-016-0440-y"},{"key":"e_1_2_18_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14086"},{"key":"e_1_2_18_44_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i27.3488"},{"key":"e_1_2_18_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000957"},{"key":"e_1_2_18_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2020.12.005"},{"key":"e_1_2_18_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-017-2114-2"},{"key":"e_1_2_18_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001216"},{"key":"e_1_2_18_49_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP8H2VBDSCIOBF"},{"key":"e_1_2_18_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182a0218f"},{"key":"e_1_2_18_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200206000-00010"},{"key":"e_1_2_18_52_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/88405305"},{"key":"e_1_2_18_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.131"},{"key":"e_1_2_18_54_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1572-0241.2003.04006.x"},{"key":"e_1_2_18_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2007.07.018"},{"key":"e_1_2_18_56_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1344760"},{"key":"e_1_2_18_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.169"},{"key":"e_1_2_18_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30223.x"},{"key":"e_1_2_18_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283426313"},{"key":"e_1_2_18_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.12.031"},{"key":"e_1_2_18_61_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-123186"},{"key":"e_1_2_18_62_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446149"},{"key":"e_1_2_18_63_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.1551-18"},{"key":"e_1_2_18_64_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.1097"},{"key":"e_1_2_18_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.09.017"},{"key":"e_1_2_18_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2012.01253.x"},{"key":"e_1_2_18_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001008"},{"key":"e_1_2_18_68_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504910"},{"key":"e_1_2_18_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12159"},{"key":"e_1_2_18_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23092"},{"key":"e_1_2_18_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8950"},{"key":"e_1_2_18_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2016.03.002"},{"key":"e_1_2_18_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2016.12.1218"},{"key":"e_1_2_18_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12320"},{"key":"e_1_2_18_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30234-6"},{"key":"e_1_2_18_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-019-06871-2"},{"key":"e_1_2_18_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.02.048"},{"key":"e_1_2_18_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.512"},{"key":"e_1_2_18_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328360b9ec"},{"key":"e_1_2_18_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005154"},{"key":"e_1_2_18_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12441"},{"key":"e_1_2_18_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23605"},{"key":"e_1_2_18_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-005-0583-x"},{"key":"e_1_2_18_84_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.03.091"},{"key":"e_1_2_18_85_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.5137"},{"key":"e_1_2_18_86_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6669-1"},{"key":"e_1_2_18_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-018-4052-y"},{"key":"e_1_2_18_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.05.019"},{"key":"e_1_2_18_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23762"},{"key":"e_1_2_18_90_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.6519"},{"key":"e_1_2_18_91_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2015.1704"},{"key":"e_1_2_18_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29619"},{"key":"e_1_2_18_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25486"},{"key":"e_1_2_18_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-018-1540-1"},{"key":"e_1_2_18_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2017.12.011"},{"key":"e_1_2_18_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25140"},{"key":"e_1_2_18_97_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14530"},{"key":"e_1_2_18_98_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2012.1962"},{"key":"e_1_2_18_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2019.12.025"},{"key":"e_1_2_18_100_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07353-4"},{"key":"e_1_2_18_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.06.025"},{"key":"e_1_2_18_102_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4239-8"},{"key":"e_1_2_18_103_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003788"},{"key":"e_1_2_18_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28744"},{"key":"e_1_2_18_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25737"},{"key":"e_1_2_18_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30045-1"},{"key":"e_1_2_18_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182708b57"},{"key":"e_1_2_18_108_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-09905-z"},{"key":"e_1_2_18_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2012.06195.x"},{"key":"e_1_2_18_110_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2011.771"},{"key":"e_1_2_18_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.03.035"},{"key":"e_1_2_18_112_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182822277"},{"key":"e_1_2_18_113_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.008"},{"key":"e_1_2_18_114_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002574"},{"key":"e_1_2_18_115_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220527"},{"key":"e_1_2_18_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2021.102258"},{"key":"e_1_2_18_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2003.07.015"},{"key":"e_1_2_18_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00318.x"},{"issue":"5","key":"e_1_2_18_119_1","article-title":"PHOTOSTENT\u201002: porfimer sodium photodynamic therapy plus stenting versus stenting alone in patients with locally advanced or metastatic biliary tract cancer","volume":"3","author":"Pereira SP","year":"2018","journal-title":"ESMO Open"},{"key":"e_1_2_18_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.10.029"},{"key":"e_1_2_18_121_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-124870"},{"key":"e_1_2_18_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-020-07689-z"},{"key":"e_1_2_18_123_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6131-9"},{"key":"e_1_2_18_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2019.05.020"},{"key":"e_1_2_18_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.08.013"},{"key":"e_1_2_18_126_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.3778"},{"key":"e_1_2_18_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.04.020"},{"key":"e_1_2_18_128_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20180688"},{"key":"e_1_2_18_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.07.008"},{"key":"e_1_2_18_130_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.2219"},{"key":"e_1_2_18_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30915-X"},{"key":"e_1_2_18_132_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.5381"},{"key":"e_1_2_18_133_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-020-1459-x"},{"key":"e_1_2_18_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10831"},{"key":"e_1_2_18_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10776"},{"key":"e_1_2_18_136_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00050"},{"key":"e_1_2_18_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a010676"},{"key":"e_1_2_18_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-009-1055-0"},{"issue":"9","key":"e_1_2_18_139_1","first-page":"5193","article-title":"First\u2010line treatment of advanced biliary ducts carcinoma: a randomized phase II study evaluating 5\u2010FU\/LV plus oxaliplatin (Folfox 4) versus 5\u2010FU\/LV (de Gramont regimen)","volume":"37","author":"Schinzari G","year":"2017","journal-title":"Anticancer Res"},{"key":"e_1_2_18_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603648"},{"key":"e_1_2_18_141_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365781"},{"key":"e_1_2_18_142_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908721"},{"key":"e_1_2_18_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605779"},{"key":"e_1_2_18_144_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt540"},{"key":"e_1_2_18_145_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh351"},{"key":"e_1_2_18_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70212-8"},{"key":"e_1_2_18_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.299"},{"key":"e_1_2_18_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.10.004"},{"key":"e_1_2_18_149_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz058"},{"key":"e_1_2_18_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2018.11.018"},{"key":"e_1_2_18_151_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.3277"},{"key":"e_1_2_18_152_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.4018"},{"key":"e_1_2_18_153_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2020-0247"},{"key":"e_1_2_18_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.08.2082"},{"key":"e_1_2_18_155_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2012.682628"},{"key":"e_1_2_18_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-013-2090-4"},{"key":"e_1_2_18_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12218"},{"key":"e_1_2_18_158_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8590"},{"key":"e_1_2_18_159_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.4_suppl.205"},{"key":"e_1_2_18_160_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy282"},{"key":"e_1_2_18_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00139-4"},{"key":"e_1_2_18_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00043-7"},{"key":"e_1_2_18_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00727-4"},{"key":"e_1_2_18_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.08.003"},{"key":"e_1_2_18_165_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu162"},{"key":"e_1_2_18_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29471"},{"key":"e_1_2_18_167_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-015-0267-x"},{"key":"e_1_2_18_168_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-017-3353-2"},{"key":"e_1_2_18_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.01.019"},{"key":"e_1_2_18_170_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33146"},{"key":"e_1_2_18_171_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-015-2919-0"},{"key":"e_1_2_18_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0138-2"},{"key":"e_1_2_18_173_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.6166"},{"key":"e_1_2_18_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00027-9"},{"key":"e_1_2_18_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3375"},{"key":"e_1_2_18_176_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2016.09.01"},{"key":"e_1_2_18_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.033"},{"key":"e_1_2_18_178_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0368"},{"key":"e_1_2_18_179_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29764"},{"key":"e_1_2_18_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.10.013"},{"key":"e_1_2_18_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30157-1"},{"key":"e_1_2_18_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30109-1"},{"key":"e_1_2_18_183_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206834"},{"key":"e_1_2_18_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0334-0"},{"key":"e_1_2_18_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00196-5"},{"key":"e_1_2_18_186_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.4009"},{"key":"e_1_2_18_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00336-3"},{"key":"e_1_2_18_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36399-y"},{"key":"e_1_2_18_189_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2022-0214"},{"key":"e_1_2_18_190_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00606"},{"key":"e_1_2_18_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00242-5"},{"key":"e_1_2_18_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02321-8"},{"key":"e_1_2_18_193_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy432.007"},{"key":"e_1_2_18_194_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.5009"},{"key":"e_1_2_18_195_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.34.4_suppl.335"},{"key":"e_1_2_18_196_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.330"},{"key":"e_1_2_18_197_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.2500"},{"key":"e_1_2_18_198_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.9473"},{"key":"e_1_2_18_199_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-011-9719-0"},{"key":"e_1_2_18_200_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.4_suppl.187"},{"key":"e_1_2_18_201_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-0697"},{"key":"e_1_2_18_202_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.3_suppl.299"},{"key":"e_1_2_18_203_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.2048"},{"key":"e_1_2_18_204_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.6785"},{"key":"e_1_2_18_205_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013-0352"},{"key":"e_1_2_18_206_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714448"},{"key":"e_1_2_18_207_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02105"},{"key":"e_1_2_18_208_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6733"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T03:51:53Z","timestamp":1728445913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.15948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,5]]},"references-count":207,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/liv.15948"],"URL":"https:\/\/doi.org\/10.1111\/liv.15948","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,5]]},"assertion":[{"value":"2023-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}