{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:16:13Z","timestamp":1782562573836,"version":"3.54.5"},"reference-count":72,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Steatotic liver disease (SLD) is generally considered to represent a hepatic manifestation of metabolic syndrome and includes a disease spectrum comprising isolated steatosis, metabolic dysfunction\u2010associated steatohepatitis, liver fibrosis and ultimately cirrhosis. A better understanding of the detailed underlying pathogenic mechanisms of this transition is crucial for the design of new and efficient therapeutic interventions. Thymocyte differentiation antigen (Thy\u20101, also known as CD90) expression on fibroblasts controls central functions relevant to fibrogenesis, including proliferation, apoptosis, cytokine responsiveness, and myofibroblast differentiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The impact of Thy\u20101 on the development of SLD and progression to fibrosis was investigated in high\u2010fat diet (HFD)\u2010induced SLD wild\u2010type and Thy\u20101\u2010deficient mice. In addition, the serum soluble Thy\u20101 (sThy\u20101) concentration was analysed in patients with metabolic dysfunction\u2010associated SLD stratified according to steatosis, inflammation, or liver fibrosis using noninvasive markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We demonstrated that Thy\u20101 attenuates the development of fatty liver and the expression of profibrogenic genes in the livers of HFD\u2010induced SLD mice. Mechanistically, Thy\u20101 directly inhibits the profibrotic activation of nonparenchymal liver cells. In addition, Thy\u20101 prevents palmitic acid\u2010mediated amplification of the inflammatory response of myeloid cells, which might indirectly contribute to the pronounced development of liver fibrosis in Thy\u20101\u2010deficient mice. Serum analysis of patients with metabolically associated steatotic liver disease syndrome revealed that sThy\u20101 expression is correlated with liver fibrosis status, as assessed by liver stiffness, the Fib4 score, and the NAFLD fibrosis score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data strongly suggest that Thy\u20101 may function as a fibrosis\u2010protective factor in mouse and human SLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15956","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T03:15:32Z","timestamp":1714792532000},"page":"2075-2090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Thy\u20101 restricts steatosis and liver fibrosis in steatotic liver disease"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0457-4135","authenticated-orcid":false,"given":"Valentin","family":"Blank","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine II Leipzig University Medical Center  Leipzig Germany"},{"name":"Division of Interdisciplinary Ultrasound, Department of Internal Medicine I \u2010 Gastroenterology and Pneumology University Hospital Halle  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8109-8526","authenticated-orcid":false,"given":"Thomas","family":"Karlas","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine II Leipzig University Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Anderegg","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and 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