{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:25:42Z","timestamp":1792686342480,"version":"4.5.0"},"reference-count":159,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heme is a primordial macrocycle upon which most aerobic life on Earth depends. It is essential to the survival and health of nearly all cells, functioning as a prosthetic group for oxygen\u2010carrying proteins and enzymes involved in oxidation\/reduction and electron transport reactions. Heme is essential for the function of numerous hemoproteins and has numerous other roles in the biochemistry of life. In mammals, heme is synthesised from glycine, succinyl\u2010CoA, and ferrous iron in a series of eight steps. The first and normally rate\u2010controlling step is catalysed by 5\u2010aminolevulinate synthase (ALAS), which has two forms: ALAS1 is the housekeeping form with highly variable expression, depending upon the supply of the end\u2010product heme, which acts to repress its activity; ALAS2 is the erythroid form, which is regulated chiefly by the adequacy of iron for erythroid haemoglobin synthesis. Abnormalities in the several enzymes of the heme synthetic pathway, most of which are inherited partial enzyme deficiencies, give rise to rare diseases called porphyrias. The existence and role of heme importers and exporters in mammals have been debated. Recent evidence established the presence of heme transporters. Such transporters are important for the transfer of heme from mitochondria, where the penultimate and ultimate steps of heme synthesis occur, and for the transfer of heme from cytoplasm to other cellular organelles. Several chaperones of heme and iron are known and important for cell health. Heme and iron, although promoters of oxidative stress and potentially toxic, are essential cofactors for cellular energy production and oxygenation.<\/jats:p>","DOI":"10.1111\/liv.15965","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T07:50:49Z","timestamp":1718697049000},"page":"2235-2250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Update on heme biosynthesis, <scp>tissue\u2010specific<\/scp> regulation, heme transport, relation to iron metabolism and cellular energy"],"prefix":"10.1111","volume":"44","author":[{"given":"Audrey","family":"Belot","sequence":"first","affiliation":[{"name":"Center for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herve","family":"Puy","sequence":"additional","affiliation":[{"name":"Centre Fran\u00e7ais des Porphyries Assistance Publique\u2010H\u00f4pitaux de Paris (APHP), Universit\u00e9 de Paris Cit\u00e9, INSERM U1149  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqbal","family":"Hamza","sequence":"additional","affiliation":[{"name":"Center for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine University of Maryland  Baltimore Maryland USA"},{"name":"Department of Animal and Avian Sciences University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7387-3230","authenticated-orcid":false,"given":"Herbert L.","family":"Bonkovsky","sequence":"additional","affiliation":[{"name":"Section on Gastroenterology &amp; Hepatology, Department of Medicine Wake Forest University School of Medicine, Atrium Health Wake Forest Baptist  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1608634"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2019.06.003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1142\/7484"},{"key":"e_1_2_8_5_1","first-page":"378","volume-title":"Hepatology: a Textbook of Liver Disease","author":"Bonkovsky HL","year":"1990"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20145-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02794.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510270627"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700547104"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)68459-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00214a012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.61.2.748"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63477-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2500189"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1994.tb02184.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180119"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117381"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1996.0112h.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00225252"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.11.2835"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf516"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23401"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2008.01.006"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6346fje"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409463200"},{"key":"e_1_2_8_27_1","first-page":"1050","article-title":"Intravenous heme\u2010albumin in acute intermittent porphyria: evidence for repletion of hepatic hemoproteins and regulatory heme pools","volume":"86","author":"Bonkovsky HL","year":"1991","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.180844"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1309915111"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc6479"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1105010"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200509262"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.116483"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar040020w"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R112.422642"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9cs00268e"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(81)90039-8"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1774-2"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.146076"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00115"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030740"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26982"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1661666"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04724.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(01)00187-7"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.12.080"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S281631"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2305601"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.013"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022018662"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90739-y"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20050354"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2010.10.008"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1825809"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.6.2051"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291x(83)91257-3"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.215772"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.719161"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.04.017"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401845101"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(86)90262-x"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(73)90136-0"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(76)90072-x"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)68575-3"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.06.040"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2001.5386"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)40571-0"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-015-0024-z"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-1119(00)00103-7"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi101585c"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40628-7"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio807"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-9589-5_2"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2017.01.006"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00061"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001044"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06934"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.01.005"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.326785"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.49503"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118881"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.220178"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00690-10"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI136727"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01294-5"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6242262422"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1151133"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.114488"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030579"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.07.013"},{"key":"e_1_2_8_91_1","doi-asserted-by":"crossref","unstructured":"SonY KennyTC KhanA BirsoyK HiteRK.Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1.bioRxiv2023. doi:10.1101\/2023.09.28.560019","DOI":"10.1101\/2023.09.28.560019"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.02.014"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.04.003"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.03.030"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05591.x"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2111617119"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-062320-112625"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9001116"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1523802113"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1609865113"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00007"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4mt00246f"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb5009734"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.01.034"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008133107"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20140220"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.013802"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)38600-3"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr800395x"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi300863a"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206940"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-020-00274-w"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b00756"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.12.009"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi7013739"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135896"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0889-8588(05)70343-9"},{"key":"e_1_2_8_118_1","first-page":"38","article-title":"Hemolytic anemia","volume":"36","author":"Beutler E","year":"1999","journal-title":"Semin Hematol"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010288"},{"key":"e_1_2_8_120_1","first-page":"2599","article-title":"Hemolytic anemia","volume":"69","author":"Dhaliwal G","year":"2004","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-234"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-174466"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4878"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-018-2509-9"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(99)00027-7"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00187"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1974.tb03386.x"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi960371l"},{"key":"e_1_2_8_129_1","first-page":"7","article-title":"Binding of heme to human serum albumin: steady\u2010state fluorescence, circular dichroism and optical difference spectroscopic studies","volume":"42","author":"Kamal JK","year":"2005","journal-title":"Indian J Biochem Biophys"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2020.118298"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32564-5"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126408"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00465"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158174"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042199"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.2147\/TACG.S48605"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-6-200503150-00010"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw013"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.4.797"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010051"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12899"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/35093131"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12876"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.010"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(90)90169-s"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.04.008"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.42.27580"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.03.032"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv222"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2018.12.012"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2023.11.007"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13091923"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109252"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01540"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1913147"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-017-0451-1"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(88)90006-1"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)51088-2"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)69552-9"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1142\/9789812775733_0041"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:55:32Z","timestamp":1760187332000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.15965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":159,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/liv.15965"],"URL":"https:\/\/doi.org\/10.1111\/liv.15965","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,18]]},"assertion":[{"value":"2024-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}