{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:34:25Z","timestamp":1791304465041,"version":"4.3.1"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Small series suggest that rituximab could be effective as treatment for autoimmune hepatitis (AIH), although data are scarce. We aimed to evaluate the efficacy and safety of rituximab in different cohorts of patients with AIH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicentre retrospective analysis of the 35 patients with AIH and its variant forms treated with rituximab and included in the ColHai registry between 2015 and 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients were female (83%), 10 (29%) had cirrhosis and four (11.4%) variant forms of AIH. Indication for rituximab were as follows: 14(40%) refractory AIH, 19(54%) concomitant autoimmune or haematological disorder, 2(6%) intolerance to prior treatments. In three (9%) subjects with a concomitant disorder, rituximab was the first therapy for AIH. Overall, 31 (89%) patients achieved or maintained complete biochemical response (CBR), including the three in first\u2010line therapy. No difference in CBR was observed according to rituximab indication (refractory AIH 86% vs. concomitant disorders 90%, <jats:italic>p<\/jats:italic>\u2009=\u2009.824) or cirrhosis (80% vs. 92%, <jats:italic>p<\/jats:italic>\u2009=\u2009.319). Rituximab was associated with a significant reduction in corticosteroids (median dose: prior 20 vs. post 5\u2009mg, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and the discontinuation of \u22651 immunosuppressant in 47% of patients. Flare\u2010free rate at 1st, 2nd and 3rd year was 86%, 73% and 62% respectively. Flares were not associated with the development of liver failure and were successfully managed with repeated doses of rituximab and\/or increased corticosteroids. Three (9%) patients experienced infusion\u2010related adverse events (1 anaphylaxis and 2 flu\u2010like symptoms) and five (14%) infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rituximab is safe and effective in patients with refractory AIH and those treated due to concomitant autoimmune or haematological disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15970","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T09:14:01Z","timestamp":1716974041000},"page":"2303-2314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Rituximab is a safe and effective alternative treatment for patients with autoimmune hepatitis: Results from the <scp>ColHai<\/scp> registry"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9309-2052","authenticated-orcid":false,"given":"Mar","family":"Riveiro\u2010Barciela","sequence":"first","affiliation":[{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Liver Unit, Internal Medicine Department Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Instituto de Salud Carlos III  Madrid Spain"},{"name":"European Reference Network on Hepatological Diseases (ERN RARE\u2010LIVER)  Eppendorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4368-8939","authenticated-orcid":false,"given":"Ana","family":"Barreira\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Liver Unit, Internal Medicine Department Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Esteban","sequence":"additional","affiliation":[{"name":"Liver Unit, Internal Medicine Department Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Rota","sequence":"additional","affiliation":[{"name":"Liver Unit, Gastroenterology Department Hospital Universitario de Bellvitge, IDIBELL  L'hospitalet Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"\u00c1lvarez\u2010Navasc\u00faes","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Universitario Central de Asturias  Oviedo 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Toledo  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5547-2801","authenticated-orcid":false,"given":"Carlos","family":"Ferre\u2010Aracil","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department Hospital Universitario Puerta de Hierro Majadahonda  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Horta","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Universitari Mutua de Terrassa  Terrassa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"D\u00edaz\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL) Marqu\u00e9s de Valdecilla University Hospital  Santander 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