{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:13:07Z","timestamp":1790727187230,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Porphyria cutanea tarda (PCT) is the commonest of the porphyrias (<jats:italic>Semin Liver Dis<\/jats:italic> 1998;18:67). It often occurs secondary to an underlying internal disorder, has significant impacts on liver health and longevity, and is a treatable disease. Thus, for the clinician, recognising the disease to make the correct diagnosis, identifying causative underlying diseases, and treating the porphyria and its complications, are crucial. Although reviews on the management of PCT have been written, there have recently been significant advances in the understanding of the factors predisposing to the disease, and of its wider health impacts. This review aims to help the clinician to diagnose and manage patients with PCT, with an emphasis on the impact of recent advances on clinical management.<\/jats:p>","DOI":"10.1111\/liv.15980","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T07:53:39Z","timestamp":1717055619000},"page":"2191-2196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The clinical management of porphyria cutanea tarda: An update"],"prefix":"10.1111","volume":"44","author":[{"given":"R. P. E.","family":"Sarkany","sequence":"first","affiliation":[{"name":"Photobiology and Cutaneous Porphyria Unit St. John's Institute of Dermatology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1567-1678","authenticated-orcid":false,"given":"J. D.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Division of Hematology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00825.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90403-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12640"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02932.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04591.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03076.x"},{"key":"e_1_2_8_8_1","first-page":"58.1","volume-title":"Rook's Textbook of Dermatology","author":"Sarkany RPE","year":"2024"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1983.tb02176.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90287-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007142"},{"key":"e_1_2_8_12_1","first-page":"405","article-title":"Uroporphyrinogen decarboxylase and protoporphyrinogen oxidase in dual porphyria","volume":"76","author":"Sturrock ED","year":"1989","journal-title":"S Afr Med J"},{"key":"e_1_2_8_13_1","first-page":"405","article-title":"Dual porphyria of coexisting variegata and cutanea tarda","volume":"33","author":"Sieg I","year":"1995","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700547104"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(99)00029-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2019.01.004"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90670-C"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.5.1565.005k42_1565_1571"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160603"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1992.tb02693.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12222"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09436-6"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013746828074"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15502"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2000.111024"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljac112"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12676478"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555561346350"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1984.tb06632.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0923-1811(94)90092-2"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.08.038"},{"key":"e_1_2_8_32_1","first-page":"119","article-title":"Chloroquine in treatment of porphyria cutanea tarda. Long\u2010term efficacy of combined phlebotomy and high\u2010dose chloroquine therapy","volume":"100","author":"Wennersten G","year":"1982","journal-title":"Acta Derm Venereol Suppl (Stockh)"},{"key":"e_1_2_8_33_1","first-page":"115","article-title":"Uroporphyrinogen\u2010decarboxylase deficiencies: porphyria cutanea tarda and related conditions","volume":"5","author":"Mascaro JM","year":"1986","journal-title":"Semin Dermatol"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)82010-5"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.07.082"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-019-1051-3"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:55:01Z","timestamp":1760187301000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.15980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/liv.15980"],"URL":"https:\/\/doi.org\/10.1111\/liv.15980","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,30]]},"assertion":[{"value":"2023-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}