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Various methods of gene transfer have been developed to enable the production of the deficient enzyme or protein. One of the most important is adeno\u2010associated virus vectors, which have been shown to be viable for use in in\u00a0vivo gene therapy. Several gene therapies have already been approved. They are also promising for acquired diseases. Important examples include gene therapy for haemophilia A and B, X\u2010linked myotubular myopathy, spinal muscular atrophy and several liver diseases such as Criggler\u2010Najjar disease, alpha\u20101 antitrypsin deficiency and Fabry disease. However, the introduction of a foreign compound into hepatocytes leads to hepatic reactions with heterogeneous phenotypic expression and a wide spectrum of severity, ranging from mild transaminase elevation to acute liver failure. Several mechanisms appear to be involved in liver injury, including an immune response, but also direct toxicity depending on the method of gene transfer. As a result, the incidence, expression and severity of liver injury vary from indication to indication and from patient to patient. Patients treated for haemophilia A are more prone to transaminase elevation than those treated for haemophilia B. Corticosteroids are successfully used to correct liver reactions but also to prevent degradation of the transferred gene and loss of therapeutic activity. The aim of this review is to describe the risk of liver injury according to the indication for gene therapy and the short\u2010 and long\u2010term management currently proposed to prevent or correct liver reactions in clinical practice.<\/jats:p>","DOI":"10.1111\/liv.16065","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T11:27:36Z","timestamp":1725881256000},"page":"3121-3137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Drug\u2010induced liver injury related to gene therapy: A new challenge to be managed"],"prefix":"10.1111","volume":"44","author":[{"given":"Dominique","family":"Larrey","sequence":"first","affiliation":[{"name":"Liver Unit Saint\u2010Eloi Hospital, INSERM 1183, Montpellier School of Medicine  Montpellier 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