{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:31:40Z","timestamp":1790857900233,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Hepatitis C virus (HCV) burden is higher among people in prison given high prevalence of injecting drug use. This study evaluated direct\u2010acting antiviral (DAA) treatment outcome in prisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Surveillance and Treatment of Prisoners with hepatitis C (SToP\u2010C) study enrolled individuals incarcerated in four Australian prisons (2017\u20132019). Participants with detectable HCV RNA were offered sofosbuvir\u2010velpatasvir for 12\u2009weeks. Sustained virological response (SVR) was assessed in intention\u2010to\u2010treat (ITT; participants commencing treatment and due for SVR assessment before study close) and per\u2010protocol (PP; participants with documented treatment completion and SVR assessment) populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 799 participants with HCV, 324 (41%) commenced treatment (94% male; median age, 32\u2009years; median duration of incarceration, 9\u2009months). In ITT population (<jats:italic>n<\/jats:italic>\u2009=\u2009310), 201 had documented treatment completion (65% [95% CI: 59\u201370]), and 137 achieved SVR (ITT\u2010SVR: 44% [95% CI: 39\u201350]). In PP population (<jats:italic>n<\/jats:italic>\u2009=\u2009143), 137 achieved SVR (PP\u2010SVR: 96% [95% CI: 91\u201398]). Six participants had quantifiable HCV RNA at SVR assessment from treatment failure (<jats:italic>n<\/jats:italic>\u2009=\u20092) or reinfection (<jats:italic>n<\/jats:italic>\u2009=\u20094). Release or inter\u2010prison transfer was common reasons for no documented treatment completion (<jats:italic>n<\/jats:italic>\u2009=\u2009106\/109 [97%]) and no SVR assessment (<jats:italic>n<\/jats:italic>\u2009=\u200957\/58 [98%]). In ITT analysis, longer incarceration was associated with increased SVR (adjusted OR per month 1.03 [95% CI: 1.01\u20131.04]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among participants who completed DAA treatment and were assessed for SVR, treatment outcome was consistent with non\u2010prison clinical studies. However, most individuals did not complete treatment or lacked study\u2010documented treatment outcome due to release or transfer. Strategies to accommodate dynamic prisoner populations are required to ensure continuity of HCV care, including treatment completion and post\u2010treatment care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.16074","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T06:58:50Z","timestamp":1724828330000},"page":"2996-3007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hepatitis C treatment outcome among people in prison: The <scp>SToP<\/scp>\u2010C study"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1601-2539","authenticated-orcid":false,"given":"Hannah","family":"Ryan","sequence":"first","affiliation":[{"name":"The Kirby Institute, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4741-2622","authenticated-orcid":false,"given":"Gregory J.","family":"Dore","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1833-2017","authenticated-orcid":false,"given":"Jason","family":"Grebely","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Byrne","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8048-3473","authenticated-orcid":false,"given":"Evan B.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9444-0186","authenticated-orcid":false,"given":"Marianne","family":"Martinello","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6277-8887","authenticated-orcid":false,"given":"Andrew R.","family":"Lloyd","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2212-2028","authenticated-orcid":false,"given":"Behzad","family":"Hajarizadeh","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(21)00472-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(19)30085-8"},{"key":"e_1_2_11_4_1","unstructured":"Penal Reform International.Global Prison Trends.2022.https:\/\/cdn.penalreform.org\/wp\u2010content\/uploads\/2022\/05\/GPT2022.pdf"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2214-109x(23)00057-8"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)30466-4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(20)30365-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01680-0"},{"key":"e_1_2_11_9_1","unstructured":"World Health Organisation.Global health sector strategies on respectively HIV viral hepatitis and sexually transmitted infections for the period 2022\u20132030.2022.https:\/\/www.who.int\/publications\/i\/item\/9789240053779"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01320-X"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1702417"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512610"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(17)30404-1"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(18)30304-2"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa263"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.01.012"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(21)00077-7"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13895"},{"key":"e_1_2_11_19_1","volume-title":"Surveillance and Treatment of Prisoners with Hepatitis C (SToP\u2010C)","author":"Kirby Institute","year":"2023"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240201"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2020.02.012"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.04.019"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2019.102608"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.16137"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2023.100750"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30756-4"},{"key":"e_1_2_11_27_1","unstructured":"HajarizadehBC DoreG.Monitoring hepatitis C treatment uptake in Australia.2023.https:\/\/www.kirby.unsw.edu.au\/research\/reports\/monitoring\u2010hepatitis\u2010c\u2010treatment\u2010uptake\u2010australia\u2010issue\u201013\u2010july\u20102023"},{"key":"e_1_2_11_28_1","doi-asserted-by":"crossref","unstructured":"WillisM.Supported housing for prisoners returning to the community: A review of the literature.2018. Research Report no 7.https:\/\/www.aic.gov.au\/publications\/rr\/rr7","DOI":"10.52922\/rr204747"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/681301"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa064115"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.08.640"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30536-5"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4344-1"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac350"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac246"},{"key":"e_1_2_11_36_1","unstructured":"HeardSI GeddesL MaherL.Australian NSP survey: Prevalence of HIV HCV and injecting and sexual behaviour among NSP attendees 25\u2010year National Data Report 1995\u20132019.2020.https:\/\/www.kirby.unsw.edu.au\/sites\/default\/files\/documents\/ANSPS_25\u2010Year\u2010National\u2010Data\u2010Report\u20101995\u20102019.pdf"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2020.102693"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/09687637.2018.1494135"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12954-021-00494-4"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.15477"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14012"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxx019"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2020.102707"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)32259-1"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.9041"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.16074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T07:10:26Z","timestamp":1729667426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.16074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,27]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/liv.16074"],"URL":"https:\/\/doi.org\/10.1111\/liv.16074","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,27]]},"assertion":[{"value":"2024-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}